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| L-Carnitine |
Last updated: Jan 05, 2009 |
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L-Carnitine is not an amino acid in the strict sense, but it bears similarity to amino acids and is usually grouped under that heading. It is also a vitamin-like nutrient related to the B vitamins. L-Carnitine is used by the body to transport long chain fatty acids to the mitochondria in your cells, where it is burned for energy. Since this fat burning is such a major source of muscular energy, deficiencies in carnitine are manifested as low energy levels and muscular weakness. They can also appear as mental confusion or cloudiness, angina (heart pain) and weight gain.
Carnitine can be manufactured in the body provided the necessary vitamins and minerals are present. These include vitamin B1, B6, C, and iron. The amino acids lysine and methionine are also needed. Carnitine is present in meat, particularly beef, sheep, and lamb. Other animal foods such as milk, cheese, and poultry contain somewhat less carnitine. The available research on L-carnitine supplementation does not appear to support claims of enhanced aerobic or anaerobic exercise performance.
Carnitine supplementation can help prevent fatty build-up in the heart and liver (especially likely if you are a regular consumer of alcoholic beverages).
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L-Carnitine can help with the following: | |  | | | | Aging | Alzheimer's Disease | In 19 male and 14 female subjects (mean ages 73.9 and 76.2 years, respectively) with Alzheimer's disease who were non-responders to acetylcholinesterase inhibitor therapy, subjects were given in addition to their donepezil at 5mg/day or rivastigmine at 3mg, BID, acetyl-L-carnitine at 2gm/day, BID. There was an improvement in responders from 38% with drug therapy alone to 50% with the addition of acetyl-L-carnitine. [Curr Med Res Opin. 2003;19(4): pp.350-353] |
| Autoimmune |
Hyperthyroidism | In a double-blind, placebo-controlled trial, 50 women with normal thyroid function were given thyroid hormone and randomly assigned to three groups: placebo for six months; placebo for two months followed by 2gm or 4gm per day of L-carnitine for months three and four, then placebo for months five and six; or 2gm or 4gm per day of L-carnitine for the first four months followed by two months of placebo. Clinical symptoms such as palpitations and biochemical parameters worsened when patients took placebo, and returned to baseline or improved minimally during L-carnitine treatment. Bone loss is normally experienced during a hyperthyroid state, but bone mineral density improved throughout the trial in all patients taking L-carnitine. The authors suggest the supplement may be useful for both preventing and treating hyperthyroidism. [J Clin Endocrinol Metab 2001;86(8): pp.3579-94] |
| Circulation |
Angina | Several clinical trials have demonstrated that carnitine supplementation improves angina and heart disease. Improvements have been noted in exercise tolerance and heart function. In one study of patients with stable angina, oral administration of 900mg of L-carnitine increased mean exercise time and the time necessary for abnormalities to occur on a stress test. These results indicate that carnitine may be an effective alternative to other anti-angina agents, especially in patients with chronic stable angina. [ Drugs Exp Clin Res 1991;17(4): pp.225-35, Eur Heart J 1996 Mar;17(3): pp.414-20] |
Mitral Valve Prolapse | L-carnitine is an amino acid that acts as a shuttle for fat that is required for cellular metabolism and also acts to strengthen the heart. Dosage: 500-1,000mg two to three times daily. Acetyl-l-carnitine is a related nutrient that may be more bio-available. Dosage: 120mg three times daily. |
Congestive Heart Failure | Carnitine seems to help people who have suffered congestive heart failure. [Drugs 34 1987: pp.1-24, Arzneim Forsch 42 1992: pp.1101-4] |
Atherosclerosis | Dosage: 750 to 1,500mg bid. Important in fatty acid metabolism, depleted in cardiac muscle during acute infarctions. |
Arrhythmias/Dysrhythmias | In a controlled trial, patients with exercise induced angina received L-carnitine at a dose of 2gm per day. After 6 months, compared to controls, they had a significant reduction in the number of premature ventricular contractions at rest and increased tolerance during exercise. Improvements were noticeable after 1 month and became more pronounced with continued treatment. [Drugs Exp Clin Res 17: pp.225-35, 1991] |
Cardiomyopathy | There is a little evidence that carnitine may be useful in cardiomyopathy. [J Child Neurol (Canada) 10: pp.2S45-2S51, 1995] A deficiency of carnitine is associated with the development of some forms of cardiomyopathy. Inherited forms of cardiomyopathy seen in children may be the most responsive to therapy with L-carnitine. Will carnitine supplementation help the average person with cardiomyopathy? While it remains unknown, some doctors recommend up to 3gm of carnitine per day for the average adult. Carnitine is thought to work well with CoQ10, the two treatments being often combined.
Carnitine deficiency may also be implicated in diabetic cardiomyopathy [ J Diabetes Complications 1999 Mar-Apr;13(2):86-90.] |
| Drug Side Effects |
Chemotherapy Side-Effects/Risks | Treatment with L-carnitine for 7 days at 4gm per day ameliorated chemotherapy-induced fatigue until the next cycle of chemotherapy in a study of 50 patients who received cisplatin or ifosfamide. [Br J Cancer 2002;86(12): pp.1854-1857] |
| Nervous System |
Neuritis/Neuropathy | L-Acetyl Carnitine (LAC) was effective and well tolerated in improving neurophysiological parameters and in reducing pain over a 1-year period. LAC is, therefore, a promising treatment option in patients with diabetic neuropathy. [Drugs R D. 2002;3(4):223-33]
Another study conducted in a British Hospital found that LAC can greatly reduce the damage caused to nerves by certain HIV drugs, even promoting nerve regeneration. [AIDS 2004;18: 1549-1560, 2004] The dose in this study was 3 grams per day (1500mg bid). |
| Organ Health |
Diabetes Type II / Risk | The amino acid L-carnitine improves insulin sensitivity in type 2 diabetes. |
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KEY |  | May do some good |  |  | Likely to help |  |  | Highly recommended |
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