A newer form of vitamin B-3 (niacin), which does not cause flushing, is inositol hexaniacinate, sometimes called inositol hexanicotinate. When six niacin molecules are attached to a large molecule of inositol, inositol hexaniacinate is the result. Inositol hexaniacinate delivers niacin in a natural slow-release way, allowing for all the cholesterol-modulating benefits of niacin with little potential for side effects such as flushing (itching, heat and redness in the skin) or liver damage. Preliminary research has shown that inositol hexaniacinate has similar actions to niacin.
Effective inositol hexanicotinate doses are similar to those of niacin, about 1500 to 3000mg daily. However, the amount of research studying the safety of inositol hexaniacinate remains limited. Therefore, if you are considering taking this supplement in amounts over several grams per day you should be under a doctorís care.