|Amino Acid / Protein|| Glutamine
| ||A pilot double-blind study of glutamine for intestinal problems in PWAs did not produce statistically significant results, quite possibly because the highest dose used was only 8 grams and most researchers now recommend doses higher than 20 grams for acute problems. However, it did show a trend towards improvement in those on higher doses. Studies of people with other conditions have found that glutamine supplementation speeds recovery and can even restore firm, healthy stools to people who have only inches (of a former 21 feet!) of intestine remaining.|
Most people think the intestine is just an organ needed for the elimination of waste, but in fact, it is a crucial part of the immune system. Like people with HIV, cancer patients on chemotherapy often suffer severe diarrhea. Charles Smigelski, RD, a nutritionist and researcher at Harvard University, reports seeing a cancer chemo patient who had disabling diarrhea for six months. Within a week on glutamine, his bowel movements were normal.
Smigelski is high on glutamine and other anti-oxidant supplements for people with HIV. He has about 100 HIV patients in his practice that are supplementing with glutamine and says, Most people report that they feel better on every level. It improves their energy, it reduces diarrhea, and it's hugely useful in wasting and dealing with oxidative stress. A ton of people swear by it. [http://www.aidsinfonyc.org/]
| ||Thymomodulin is one of at least six substances produced by the thymus gland which have been scientifically examined as a possible HIV/AIDS treatment: the others are thymosin a1, THF (thymic humoral factor), TP-5 (thymopentin), thym-uvocal, and thymostimulin. Of the six, thymomodulin, thym-uvocal, and thymostimulin are crude, or "natural," thymic extracts, |
containing a number of chemically distinct substances; the other three are made synthetically, each consisting of a
The largest published study of thymomodulin and HIV was conducted in Italy, and published in 1987. It reported on 15
patients with HIV who were treated with the drug (60 mg per day orally, as a syrup) for more than 50 days. Two of the
patients with late-stage AIDS had no change in their condition, and died shortly after the end of the study. The only one with Kaposi's sarcoma who entered the study was reported to have had "an evident clinical and laboratory improvement with remission of the neoplasia."
All of the other 12 showed resolution of fever. All of them started the study with chronic lymphadenopathy, which
disappeared in six of them. Six started with thrush, which disappeared in all but one case. The CD4/CD8 ratio (a measure
no longer considered useful) increased; and the average CD8 count decreased. (This CD8 result is opposite from all of the
anecdotal reports we have heard, a discrepancy which is unexplained.) There was also a statistically significant increase in T-helper cells. No side effects of thymomodulin were seen. And there was no increase in neopterin, an indicator of T-cell activation.
A later study, conducted in Argentina and reported at the International Conference on AIDS in Amsterdam, in July 1992,
treated 11 patients with HIV -- ten of whom had AIDS - with a combination of thymomodulin, AZT, and lithium carbonate
"which stimulates granulocytic colony forming units." Two of the patients had died by the time the results were reported;
the other nine were still on the treatment. "All have a better life-style, weight gaining, less opportunistic infection episodes, and half of them returned to work... Overall, they all improved their CD4 count."
| ||In one study, 10 patients with AIDS who were given 5 to 10gm per day of an aged garlic extract later had increased levels of natural killer cells, a higher helper:suppressor ratio, and reduced infection rates.|
| ||During the normal progression of this disease, NK cell activity begins to drop along with that of other immune cells. T4 levels routinely decrease at a rate of about 15% per year. Dr Ghoneum, who has been researching MGN-3 since 1993, reports that T4 levels can be maintained in almost every case of AIDS he has tested, and oftentimes they will even begin to increase. Although the number of patients studied has been limited, all of the patients who have taken MGN-3 reported a noticeable difference in their well-being, and have continued to use the product. Most felt that MGN-3 was instrumental in helping them stabilize their disease.|
Chlorella / Algae Products
Mistletoe (Viscum album)
| ||A German study examined the use of Iscador, a mistletoe extract, in 40 HIV-positive patients with less than 200 T4 cells/ml. Patients injected themselves subcutaneously with 0.01mg to 10mg of Iscador twice per week for eighteen weeks. The only toxicities were transient fever on the day of injection and soreness at the injection site. The researchers of this small, unblinded and unreviewed study reported that 28 of the 36 patients (77%) had increases in T4 levels of greater than 20%. Iscador should only be administered under the supervision of a doctor familiar with its use. [Gorter R, et al. Abstract PO-B28-2167. IX International Conference on AIDS. Berlin. June 1993]|
BHT (Butylated Hydroxytoluene)
| ||BHT is a potent inactivator of lipid-enveloped viruses. The viral envelope structure is physically disturbed by BHT, thereby interfering with viral adsorption to host cells. Since the virus generally believed responsible for AIDS contains a lipid envelope, BHT warrants investigation as a potential antiviral agent against the AIDS virus. Published scientific evidence strongly suggests that BHT might help in treating AIDS or ARC and that any risks can be kept small. No one expects BHT to be a cure, but if it can help in the management of AIDS and/or CMV, it would have value now until better treatments become available.|
Sugars Avoidance / Reduction
| ||Sugar and corn syrup found in many desserts impair the engulfing power of white blood cells. The worst offenders are found in canned soda, candy bars, pastry and other processed desserts. Even sugars found in fruit juice, when consumed quickly, will have a depressive effect on immune cells.|
| ||Lauric acid from coconut oil, coconut milk and fresh or cooked coconut meat, at 24gm daily for adults, may be an effective aid in the destruction of lipid-enveloped viruses such as HIV, HHV-6 (strains A and B), EBV, CMV and herpes. This treatment may be used continuously as viral resistance or immune system adaption is not expected to develop.|
| ||Reproductive physiologist Roger Short, from the University of Melbourne's obstetrics department, said a few drops of lemon juice can be a cheap, easy-to-use solution to protect women from both HIV and pregnancy. The juice should be squeezed onto a piece of sponge or cotton wool and placed into the vagina before sex, he said. ''We can show in the lab that lemon juice is very effective in immobilizing human sperm and also very effective in killing HIV... in a 20% concentration.'' |
The paper refers to additional strategies, including circumcision for men, which more than halves the risk of HIV infection. The virus appears to enter the penis via specific HIV-receptive Langerhans cells on the inner surface of the foreskin. The vagina has its own Langerhans cells that are also the main entry point for HIV in women. Men may also anoint themselves with the acidic juice to prevent transmission.
Lime juice, which has similar acid levels, can also be used. [AllAfrica.com October 4, 2002]
| ||Extended fasting should be avoided in AIDS patients, who tend to be malnourished already.|
LDN - Low Dose Naltrexone
| ||Since the mid-1980's, low dose naltrexone (LDN) has consistently demonstrated a markedly beneficial effect in the treatment of HIV/AIDS. There are a score of such patients who, even today, continue to successfully use only LDN. When combined with HAART, LDN has shown itself to be an absolute preventive for lipodystrophy, as well as a synergistic therapy that diminishes viral breakthroughs and bolsters the restoration of CD4 cell levels.|
The Promise Of Low Dose Naltrexone Therapy: Potential Benefits in Cancer, Autoimmune, Neurological and Infectious Disorders. By Elaine Moore, co-author SammyJo Wilkinson Foreword by Dr. Yash Agrawal, MD, PhD.
This is perhaps the first, and so far only book on LDN, and as such represents a milestone in the effort to bring LDN into mainstream use. Written by Elaine Moore, a high level science writer with a portfolio of previous accomplishments, her LDN book is perhaps somewhat technical and may be difficult for the untrained non-professional to follow. It delves into the sophisticated jargon of the medical research world. For example, in Chapter 5 on LDN and Cancer, there is a discussion of Zagon's work on Cyclin dependent kinases, P53 and protein 21 and how this relates to inhibition of cancer by LDN.
However, in addition to the esoteric technical sections of the book, there are also chapters devoted to the lay reader interested in learning how LDN can help them on a practical level. A listing of dispensing practitioners was included which I found contained my own office address and phone number.
The book is highly recommended for other health care practitioners who wish to get quickly up to speed in this new area of medicine which is destined to become the medical paradigm of the 21st century, casting a giant shadow over the rest of mainstream medicine.[ Comments on the LDN book by Jeffrey Dach MD]
Conventional Drugs / Information
| ||Prednisone must be used cautiously by HIV-positive individuals because it is immunosuppressive and can increase the risk of getting opportunistic infections.|
ATRIPLA contains 3 medicines, SUSTIVA (efavirenz), EMTRIVA (emtricitabine) and VIREAD (tenofovir disoproxil fumarate also called tenofovir DF) combined in one pill. EMTRIVA and VIREAD are HIV (human immunodeficiency virus) nucleoside analog reverse transcriptase inhibitors (NRTIs) and SUSTIVA is an HIV non-nucleoside analog reverse transcriptase inhibitor (NNRTI). VIREAD and EMTRIVA are the components of TRUVADA. ATRIPLA can be used alone as a complete regimen, or in combination with other anti-HIV medicines to treat people with HIV infection. ATRIPLA is for adults age 18 and over.
Plant Sterols / Sterolins (Phytosterols)
| ||The use of the mixture by HIV-infected individuals has been extensively studied. It has been shown to prevent the decline of CD4 cell numbers (a surrogate marker of disease progression), decrease the plasma viral loads of patients and maintain a relatively intact immune profile despite the chronic viral infection. This implies that the use of the immune modulator (such as Moducare) by HIV-infected individuals would prevent the deterioration of the immunity and the maintenance of effective cellular responses to the virus. [S.Afr. Med. J. (2001) 91, pp.848-850, Cell Biol. Int. (2001) 25, pp.43-49]|
Beta 1,3 Glucan
| ||The first human study on Beta-1,3-glucan's systemic effect was done in the mid 1980s's on advanced HIV infection. An increase in serum cytokines IL-1, IL-2 and Interferon was measured.|
Rye Grass Extract
| ||Exercise of any type 3 - 4 times per week or more has been associated with slower progression to AIDS at one year and with a slower progression to death from AIDS at one year in men. [Ann Epidemiol 1999;9: pp.127–31]|
Test for HIV / AIDS
| ||HIV, the virus that causes AIDS, can be diagnosed from a mouth swab as accurately as from a blood sample, Canadian scientists said. This is a pain-free, non-invasive saliva test. Researchers from McGill University in Montreal said that their saliva HIV test OraQuick HIV 1/2 was 99% accurate for HIV in high-risk populations and about 97% in low-risk populations. [The Lancet Infectious Diseases, January 24, 2012]|
Test / Monitor Hormone levels
| ||Several studies have shown that testosterone levels are generally lower and that testosterone administration alleviates fatigue and depression in men with HIV/AIDS. In one study, 80% of men reported significant improvements in their energy levels. [General Hospital Psychiatry, July 1998]|
| ||Blood levels of selenium are frequently low in people with HIV infection. Zinc supplements (45mg per day) have been shown to reduce the number of infections in people with AIDS. [Int J Immunopharmacol 1995;17: pp.719-27]|
Oxygen / Oxidative Therapies
Ozone / Oxidative Therapy
| ||Male circumcision (MC) markedly decreases the acquisition of HIV infection, the major epidemic of our time. This is the first biological intervention shown to prevent HIV infection and will not depend upon continuing behaviour change to give protection. In 1986, five years after the description of AIDS, the first article suggesting that male circumcision is associated with lower risk of human immunodeficiency virus (HIV) infection was published. During the following 15 years, different studies - almost exclusively from sub-Saharan Africa, which quickly became the centre of HIV epidemic - increasingly supported this hypothesis. For example, tribes and other defined populations with low prevalence of MC had high prevalence of HIV infection, suggesting a correlation between MC and HIV prevention.|
Despite that, there was still uncertainty among many scientists and public health scientific societies, mainly due to the fear that circumcised men have different (safer) sexual practices than men who are not, and that this and not male circumcision led to lower rates of HIV infection in circumcised men and in populations where circumcision is common. To eliminate this concern, three specifically designed trials were carried out.
In 2005, the results of the first trial showed a 60% protective effect against HIV infection among the men who were circumcised (Bertran Auvert and colleagues, PLoS Med. 2005;2:e209). The study has been conducted on the behalf of the South African National Institute for Communicable Diseases (Johannesburg) and the Institut National de la Santé et de la Recherche Médicale (ANRS Paris, France), involving 3,274 men who were randomized to receive circumcision or not. The subjects were followed over a mean period of 18.1 months, and the trial was stopped prematurely because of the high efficacy observed among circumcised patients.
In February 2007, the second and third studies found a protective effect of 53% and 51% respectively in men who were circumcised, compared to those who were not (Robert Bailey and colleagues, Lancet 2007; 369:643-56 - Ronald Gray and colleagues, Lancet. 2007; 369:657-66). The second trial enrolled 2,784 men and was carried out on the behalf of the U.S. National Institutes of Health and the Canadian Institute for Health Research, while the third study, also sponsored by the National Institutes of Health, randomised 4,996 men. Each of these trials was also stopped prematurely on 12 December 2006, due to an extremely high efficacy rate. The findings of the studies are similar, and remarkably consistent with the protective effect (58% on average) found in a systematic review of observational studies available in medical literature.
"Current data show that circumcision of adult men results in an approximately 60% reduction in acquisition of HIV infection", said Dr. George Schmid (Dept. of HIV / AIDS, World Health Organization, Geneva, Switzerland).
About 30% of men are estimated to be circumcised worldwide, although this rate is still less than 20% in Europe.
Multiple Vitamin Supplement
| ||HIV-positive men who took a multivitamin-mineral supplement had slower onset of AIDS, compared with men who did not take a supplement. [Med Tribune 1993;9:18]|| |