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| Magnesium Requirement |
Last updated: May 12, 2008 |
Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | Other conditions that may be present | It can lead to... | Recommendations
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While magnesium deficiency is fairly common, it is frequently overlooked as a source of problems. The reason is that serum magnesium levels (the test most doctors use) do not reflect body stores of magnesium. Blood levels are kept within the normal range at the expense of other tissues.
Many people do not get enough magnesium from their diet for reasons including the following: - The amount of magnesium in the soil in which the food is grown may be reduced.
- Magnesium can be lost in the processing and refining of foods and in making oils from the magnesium-rich nuts and seeds. Nearly 85% of the magnesium in grains is lost during the milling of flours.
- Soaking and boiling foods can leach magnesium into the water, so the "pot liquor" from cooking vegetables may be high in magnesium and other minerals.
- Oxalic acid in vegetables such as rhubarb, spinach and chard, and phytic acid in some grains may form insoluble salts with magnesium, causing it to be eliminated rather than absorbed.
- Supplemental vitamin D or calcium reduces magnesium uptake.
- Diets high in phosphorus (meat, milk products, lentils, seeds, beans, nuts, chocolate, peanut butter, bran) reduce magnesium uptake.
- Magnesium elimination is increased in people who use alcohol, caffeine or excess sugar, or who take diuretics or birth control pills.
- Magnesium is absorbed toward the end of the small intestine. If any portion of this area (called the ileum) has been removed, magnesium absorption will be reduced.
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Signs, symptoms & indicators of Magnesium Requirement: | |  | | | | Symptoms - General | Constant fatigue | Early symptoms of magnesium deficiency can include fatigue, anorexia, irritability, insomnia, and muscle tremors or twitching. |
Fatigue on light exertion | Early symptoms of magnesium deficiency can include fatigue. |
| Symptoms - Mind - Emotional |
Irritability | Early symptoms of magnesium deficiency can include fatigue, anorexia, irritability, insomnia, and muscle tremors or twitching. |
| Symptoms - Mind - General |
Hallucinations | Extreme deficiency may produce hallucinations or delirium. |
A 'foggy' mind
Periods of confusion/disorientation | Symptoms - Muscular |
Tight/rigid muscles | Symptoms - Nervous |
Numb/tingling/burning extremities | Symptoms - Reproductive - Female Cycle |
Carbohydrate craving during cycle | A magnesium deficiency is especially likely for women who have PMS and crave chocolate during that time. |
| Symptoms - Sleep |
(Frequent) difficulty falling asleep | Early symptoms of magnesium deficiency can include fatigue, anorexia, irritability, insomnia, and muscle tremors or twitching. |
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Conditions that suggest Magnesium Requirement: | |  | | | | Circulation | Arrhythmias/Dysrhythmias | Myocardial magnesium was measured in 8 young patients (mean age 32) with ventricular tachycardia of less than 30 seconds in duration who underwent endomyocardial biopsy. Myocardial magnesium content was lower in the 4 with cardiomyopathic and dysplastic lesions than in the 4 with inflammatory lesions (myocarditis) and 8 controls. 10gm magnesium over 24 hours caused a resolution of ventricular tachycardias and a greater than 80% reduction in ventricular extrasystoles. No response was seen in the 4 patients with inflammatory lesions. [Lancet: 1019, 1987]
In another study of heart failure patients, those with the most frequent initial ectopic beats prior to a magnesium infusion had the most significant decrease with half the number of premature ventricular contractions after the infusion. Almost all the patients who had an increase in serum magnesium greater than the median value of 0.75 mg/dl showed a decrease in premature ventricular depolarization. [ Emergency Medicine, May 1994; p.53]
Magnesium deficient individuals may have an increased risk to arrhythmias, in particular premature ventricular contractions related to impairment of the sodium-potassium-ATPase pump. |
Cardiomyopathy | Myocardial magnesium was measured in 8 young patients (mean age 32) with ventricular tachycardia of less than 30 seconds in duration who underwent endomyocardial biopsy. Histologically, 4 had myocarditis and 1 had right-ventricular dysplasia. The other 3 patients had a cardiomyopathy with electron microscopic findings consistent with intracellular calcium overload, possibly due to reduced intracellular magnesium. Myocardial magnesium content was lower in the 4 with cardiomyopathic and dysplastic lesions than in the 4 with inflammatory lesions (myocarditis) and 8 controls. 10gm magnesium over 24 hours caused a resolution of ventricular tachycardias and a greater than 80% reduction in ventricular extrasystoles. No response was seen in the 4 patients with inflammatory lesions. [Lancet: 1019, 1987]
Another study comparing patients with cardiomyopathy against controls found no difference in magnesium levels. [Biol Trace Elem Res. 2003;95: pp.11-17] How magnesium levels were measured is uncertain. |
Atherosclerosis | Experimental studies have demonstrated a correlation between magnesium deficiency and atherosclerosis, but without any clear evidence to determine the mechanisms involved. Magnesium deficiency may affect the atherosclerosis process through several different mechanisms. |
| Diet |
Chocolate Craving | Chocolate contains significant amounts of magnesium and a chocolate craving may be your body's way of trying to get more. |
| Hormones |
Hypoparathyroidism | When magnesium levels are too low, calcium levels may also fall. It appears that magnesium is important for parathyroid cells to make PTH normally. Once recognized, this is usually very easy to fix. |
| Infections |
Yeast / Candida | Mental |
Anxiety | Magnesium deficiency causes increased levels of adrenaline, which can lead to a feeling of anxiety. |
Poor Memory | Metabolic |
Bruxism (Clenching/Grinding Teeth) | According to Ploceniak, prolonged magnesium administration nearly always provides a cure for bruxism. This confirms an earlier report which claimed remarkable reductions and sometimes disappearance in the frequency and duration of grinding episodes in six patients who took assorted vitamins and minerals (which included 100mg of magnesium) for at least five weeks. When the supplement intake stopped, the symptoms returned. [Bruxism and Magnesium, My Clinical Experiences Since 1980, by C. Ploceniak (Translated from the French by James Michels)] |
Acidosis
Hangovers | It is possible that some of the hangover symptoms related to alcohol are in part due to magnesium depletion. |
Gestational Diabetes Tendency | By impairing pancreatic insulin production, magnesium deficiency may increase the tendency towards hyperglycemia in cases of gestational diabetes. [J Am Coll Nutr 15(1): pp.14-20, 1996] |
Anorexia / Starvation Tendency | Early symptoms of magnesium deficiency can include fatigue, anorexia, irritability, insomnia, and muscle tremors or twitching. |
| Musculo-Skeletal |
Leg Cramps At Night
Muscle Cramps / Twitching | Early symptoms of magnesium deficiency can include fatigue, anorexia, irritability, insomnia, and muscle tremors or twitching. Many cases of muscle cramps are caused by low concentrations of magnesium. [Muscle cramps and magnesium deficiency: case reports. Canadian Family Physician. July 1996: 42; pp.1348-1351] |
Restless Leg Syndrome (RLS) / Periodic Limb Moveme | See the treatment link between RLS and magnesium. |
| Nervous System |
Tremors | Early symptoms of magnesium deficiency can include fatigue, anorexia, irritability, insomnia, and muscle tremors or twitching. |
| Pain |
Low Back Pain / Problems | Respiratory |
Asthma | Magnesium levels are frequently low in asthmatics. [J Lab Clin Med 1940;26: pp.340-4] Current evidence suggests that high dietary magnesium intake may be associated with better lung function and reduced bronchial reactivity. Intravenous injection of magnesium has been reported in most, but not all, double-blind trials to rapidly halt acute asthma attacks. Some doctors believe that the modified "Myers' Cocktail" (which contains magnesium) will be the treatment of choice eventually for acute asthma attacks. |
| Symptoms - Reproductive - Female Cycle |
Being postmenopausal | Uro-Genital |
Premenstrual Syndrome / PMDD | Magnesium deficiency is strongly implicated as a causative factor in PMS. Red Blood Cell magnesium levels in PMS patients have been shown to be significantly lower than in normal subjects. The deficiency is characterized by a generalized hyperesthesia syndrome (with generalized aches and pains), and a lower premenstrual pain threshold. One clinical trial of magnesium in PMS showed a reduction of nervousness in 89%, mastalgia in 96%, and weight gain in 95%. |
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Risk factors for Magnesium Requirement: | |  | | | | Addictions | Alcohol-related Problems | Lab Values - Chemistries |
Hypocalcemia | Mental |
Stress | Organ Health |
Diabetes Type II / Risk | Hypomagnesemia has been demonstrated in both insulin-dependent and non-insulin-dependent diabetic patients. A low intake of magnesium, which is a common deficiency, has been associated with insulin resistance and diabetes in several studies. Magnesium deficiency in diabetes is most likely the result of increased urinary magnesium losses secondary to chronic glycosuria. However, short-term improvement in glycemic control has not been shown to restore the serum magnesium level. Long-term studies may be needed to resolve this discrepancy. |
Liver Detoxification / Support Requirement | Magnesium deficiency has been found to be more common in patients with diabetes, liver disease or malabsorption problems. |
| Supplements and Medications |
Taking calcium supplement
(Past) non-human estrogen use
Diuretic use
Current birth control pill use | Those on birth control pills should take supplemental magnesium. |
History of birth control pill use
Counter-indicators:
Multiple mineral supplement use
(Limited) magnesium supplementation | Symptoms - Food - Beverages |
(High) coffee consumption
Caffeinated soft drink consumption
High/low/moderate alcohol consumption | Symptoms - Food - Intake |
Eating sizable chocolate portions
(High) refined sugar consumption | Symptoms - Gas-Int - General |
Having had a small bowel resection | In evaluating magnesium levels in patients with small bowel resection, it was found that while serum magnesium was not abnormally low, but both urinary and muscle magnesium concentration decreased with increasing resection length. Muscular fatigue was also positively correlated to a pathologically low muscle magnesium concentration. Results suggest that clinically important magnesium deficiency occurs in patients with resections exceeding 75cm. |
| Symptoms - Reproductive - General |
(Much) recent breastfeeding |
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Magnesium Requirement suggests the following may be present:
Magnesium Requirement can lead to:
Recommendations for Magnesium Requirement:
KEY |  | Weak or unproven link |  |  | Strong or generally accepted link |  |  | Proven definite or direct link |  |  | Strongly counter-indicative |  |  | Very strongly or absolutely counter-indicative |  |  | Likely to help |  |  | Highly recommended |
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