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| | | Amino Acid / Protein | Taurine
 | Taurine reduces platelet aggregation, which is how most natural products work in stroke prevention. |
Not recommended:
Glutamine
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Animal-based |
Fish Oil / Krill
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Botanical |
Grape Seed Extract / Resveratrol
 | Previous studies have determined an association between mild-to-moderate red wine consumption with a reduced incidence of cardiovascular, cerebrovascular, and peripheral vascular risk.
Johns Hopkins University School of Medicine (Maryland, USA) researchers investigated the mechanism by which resveratrol, a compound found in the skins and seeds of red grapes, may protect against stroke.
Two hours after feeding mice a single modest dose of resveratrol, the researchers induced an ischemic stroke. Those animals that had preventively ingested the resveratrol suffered significantly less brain damage, as compared to ones that had not been given the compound.
Sylvain Dore, lead researchers of the study, posits that resveratrol increases levels of an enzyme (heme oxygenase) already known to shield nerve cells in the brain from damage. When the stroke hits, the brain is ready to protect itself because of elevated enzyme levels. In mice that lacked the enzyme, the study found, resveratrol had no significant protective effect and their brain cells died after a stroke.
The team concludes that: “The data suggest a potential intracellular pathway by which resveratrol can provide cell/organ resistance against neuropathological conditions.” |
Garlic
Cayenne Pepper (Capsicum frutescens)
 | Cayenne reduces platelet aggregation (makes the blood less likely to clot) and thus may reduce the risk of clotting strokes. |
Ginkgo Biloba
Gugulipids
Turmeric Extract, Curcumin
|
Detoxification |
Chelation Therapy
|
Diet |
Vegetarian/Vegan Diet
 | A low incidence of cerebrovascular disease was associated with geographical regions where fresh fruit and vegetable consumption (increased potassium) was high. [Low fruits and vegetables, high-meat diet increase cerebrovascular event risk. Medical Tribune March 10, 1997:26] |
Increased Fruit/Vegetable Consumption
 | Consuming at least 3 servings per day of fruit and vegetables was associated with reduced risk of stroke and death from stroke, ischemic heart disease and cardiovascular disease in a study of over 9,000 adults, free of cardiovascular disease at the beginning of a 19 year study.[Am J Clin Nutr 2002;76(1): pp.93-99] |
Increased Fish Consumption
 | Eating fish, one or more times per month, was associated with a reduced risk of ischemic stroke in a study of 43,671 men aged 40 to 75 years followed for 12 years. No associations were found between fish or long-chain omega-3 polyunsaturated fatty acid intake and risk of hemorrhagic stroke.
The use of fish oil or increased consumption of omega-3 fatty acids should have the same effect. [JAMA 2002;288(24): pp.3130-6] |
Low Fat Diet
Caffeine/Coffee Avoidance
 | Coffee, including decaf, contains significant amounts of Vitamin K which is an important factor for blood coagulation. People at high risk for blood clots, strokes, and heart attacks should avoid coffee and decaf for this reason. |
|
Drug |
Conventional Drugs / Information
 | You can increase the chance of getting the preventive effects and decrease the chance of side effects effects of any medicine by choosing and using it wisely. When it comes to using aspirin to lower the risk of heart attack and stroke, choosing and using wisely means knowing the facts and working with your health professional.
There are many reasons to believe that the drug dipyridamole (300mg per day) will be far more effective in the prevention of heart attacks and strokes than aspirin. Moreover, dipyridamole has none of the harmful side effects of aspirin.
Dipyridamole, like aspirin, inhibits platelet adhesion, and thus tends to prevent the vascular thrombosis of heart attacks and strokes. In a trial referencing the poor response to aspirin, Dipyridamole was added to the treatment protocol and the results were outstanding. Over a two-year period, stroke deaths were decreased by 50%, deaths from myocardial infarction decreased by 38% and deaths from cancer by 25%. [ European Stroke Prevention Study, Lancet, December 12, 1987; pp. 1,371-4] |
|
Extract |
Fibrinolytic Enzymes
Policosanol/Octacosanol
 | Policosanol inhibits the formation of clots, and may work synergistically with aspirin in this respect. 75% of strokes are of the clotting kind. In a comparison of aspirin and policosanol, aspirin was better at reducing one type of platelet aggregation (clumping together of blood cells) but policosanol was better at inhibiting another type. Together, policosanol and aspirin worked better than either alone. |
|
Hormone |
Testosterone
|
Mineral |
Lithium (low dose)
 | Research in experimental animals with deliberately induced ischemic strokes has shown that lithium reduces the areas of cell death. |
Potassium
 | Potassium, found in fruits and vegetables, has been shown to decrease the incidence of strokes. A low potassium diet increases the risk of stroke. [Neurology 2002;59(3): pp.314-320] |
|
Nutrient |
Lecithin / Choline / GPC
 | Research on GPC's therapeutic effect in cases of vascular dementia caused by stroke suggests that GPC may promote functional recovery. These studies were uncontrolled so additional research will be necessary to confirm this benefit. |
EPA (eicosapentanoic acid)
 | EPA reduces platelet aggregation and thus helps prevent those strokes that are due to an abnormal clotting tendency. |
Essential Fatty Acids
 | High doses of Omega-3 oils reduce platelet aggregation and thus reduce the abnormal clotting tendency which is seen in 75% of strokes. |
Alpha Lipoic Acid
|
Vitamins |
Vitamin Folic Acid
 | A study found that people with a dietary intake of at least 300mcg per day of folic acid reduced their risk of stroke and heart disease by 20% and 13%, respectively, compared with those who consumed less than 136mcg of folic acid per day. [Stroke 2002;33: pp.1183-9] |
Vitamin E
 | Vitamin E at 300 IU or above reduces platelet aggregation, as do the tocotrienols. It is interesting to note that some doctors report that starting to take large doses of vitamin E immediately after a stroke will encourage a higher level of recovery than without the use of vitamin E. For example, instead of having to use a walker, a patient may become mobile with just a cane. This was based on the work of Dr.s Wilfred and Evan Shute. They believed that vitamin E reduces ischemia commonly experienced in myocardial infarction, stroke and renal failure.
These doctors recommended doses from 400 IU to 8,000 IU daily. The usual dose range was 800 to 1600 IU but they reported that they had given 8,000 IU (about 8 grams) without seeing any toxicity.
Yet, a study reported in the June 15, 1999, issue of the "Annals of Internal Medicine" presented data derived from over 40,000 subjects -- male health professionals whose dietary intake, use of vitamin supplements and health status were followed starting in 1986.
The researchers found no difference in risk of stroke between the high vitamin E- and C-consuming subjects and those who consumed lower levels of the two nutrients. Similarly, the researchers found that a higher intake of most of the carotenoids did not decrease the risk in these men of either total stroke or ischemic stroke. Only with respect to lutein (a carotenoid found mainly in dark-green leafy vegetables) did the investigators find a weak trend of decreased risk of stroke with increased intake. |
Vitamin B6 (Pyridoxine)
 | Vitamin B6 at 150-200mg daily reduces platelet aggregation, and thus may help prevent ischemic (clotting type) strokes. |
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GLOSSARY
Anticoagulant: A substance that prevents or delays blood clots (coagulation).
Apnea: Cessation of breathing.
Arrhythmia: A condition caused by variation in the regular rhythm of the heartbeat. Arrhythmias may cause serious conditions such as shock and congestive heart failure, or even death.
Aspiration: Inhalation, or removal of fluids or gases from a cavity using suction.
Bell's Palsy: One-sided facial paralysis of sudden onset and unknown cause. The mechanism is presumed to involve swelling of the nerve due to immune or viral disease, with ischemia and compression of the facial nerve in the narrow confines of its course through the temporal bone.
Cardiac: Pertaining to the heart, also, pertaining to the stomach area adjacent to the esophagus.
Cholesterol: A waxy, fat-like substance manufactured in the liver and found in all tissues, it facilitates the transport and absorption of fatty acids. In foods, only animal products contain cholesterol. An excess of cholesterol in the bloodstream can contribute to the development of atherosclerosis.
Copper: An essential mineral that is a component of several important enzymes in the body and is essential to good health. Copper is found in all body tissues. Copper deficiency leads to a variety of abnormalities, including anemia, skeletal defects, degeneration of the nervous system, reproductive failure, pronounced cardiovascular lesions, elevated blood cholesterol, impaired immunity and defects in the pigmentation and structure of hair. Copper is involved in iron incorporation into hemoglobin. It is also involved with vitamin C in the formation of collagen and the proper functioning in central nervous system. More than a dozen enzymes have been found to contain copper. The best studied are superoxide dismutase (SOD), cytochrome C oxidase, catalase, dopamine hydroxylase, uricase, tryptophan dioxygenase, lecithinase and other monoamine and diamine oxidases.
Embolism: Obstruction of a vessel by an abnormal body, usually a detached blood clot.
Fatty Acids: Chemical chains of carbon, hydrogen, and oxygen atoms that are part of a fat (lipid) and are the major component of triglycerides. Depending on the number and arrangement of these atoms, fatty acids are classified as either saturated, polyunsaturated, or monounsaturated. They are nutritional substances found in nature which include cholesterol, prostaglandins, and stearic, palmitic, linoleic, linolenic, eicosapentanoic (EPA), and decohexanoic acids. Important nutritional lipids include lecithin, choline, gamma-linoleic acid, and inositol.
Free Radical: A free radical is an atom or group of atoms that has at least one unpaired electron. Because another element can easily pick up this free electron and cause a chemical reaction, these free radicals can effect dramatic and destructive changes in the body. Free radicals are activated in heated and rancid oils and by radiation in the atmosphere, among other things.
Hypertension: High blood pressure. Hypertension increases the risk of heart attack, stroke, and kidney failure because it adds to the workload of the heart, causing it to enlarge and, over time, to weaken; in addition, it may damage the walls of the arteries.
Iron: An essential mineral. Prevents anemia: as a constituent of hemoglobin, transports oxygen throughout the body. Virtually all of the oxygen used by cells in the life process are brought to the cells by the hemoglobin of red blood cells. Iron is a small but most vital, component of the hemoglobin in 20,000 billion red blood cells, of which 115 million are formed every minute. Heme iron (from meat) is absorbed 10 times more readily than the ferrous or ferric form.
Ischemia: Localized tissue anemia due to obstruction of the inflow of arterial blood.
Milligram: (mg): 1/1,000 of a gram by weight.
Stroke: A sudden loss of brain function caused by a blockage or rupture of a blood vessel that supplies the brain, characterized by loss of muscular control, complete or partial loss of sensation or consciousness, dizziness, slurred speech, or other symptoms that vary with the extent and severity of the damage to the brain. The most common manifestation is some degree of paralysis, but small strokes may occur without symptoms. Usually caused by arteriosclerosis, it often results in brain damage.