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| Increased Risk of Stroke |
Last updated: Apr 28, 2008 |
Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | Other conditions that may be present | It could instead be... | Recommendations
Signs, symptoms & indicators of Increased Risk of Stroke: | |  | | | | Lab Values - Common | Rapid pulse rate | See the link between Increased Risk of Coronary Disease / Heart Attack and Pulse Rate. |
Counter-indicators:
Slowed pulse rate | See the link between Increased Risk of Coronary Disease / Heart Attack and Pulse Rate. |
| Symptoms - Metabolic |
Having a slight/having a moderate/having a high fever | Fever is a frequent complication early after stroke and in the majority of cases, it can be explained by infection or chemical aspiration pneumonia. In about half of the infected patients, infection was most probably acquired before stroke. Fever was associated with a more severe neurological deficit on admission. |
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Conditions that suggest Increased Risk of Stroke: | |  | | | | Circulation | Arrhythmias/Dysrhythmias | In atrial fibrillation (AF), the erratic motion of the atria leads to blood stasis which predisposes to blood clots which may travel from the heart to the brain and other areas. Thus, AF is an important risk factor for stroke, the most feared complication of atrial fibrillation. AF may increase mortality up to 2-fold, primarily due to embolic stroke.
Atrial fibrillation is the most common clinically significant cardiac arrhythmia and a major risk factor for ischemic stroke and peripheral embolism. Anticoagulant use reduces this risk. |
Hypercoagulation (Thickened Blood) | Lab Values - Common |
Recent onset/medium-term/long-term hypertension | Respiratory |
Sleep Apnea | There is evidence suggesting that individuals with obstructive sleep apnea may be at increased risk of stroke. Researchers looking at "heavy snorers" say that their increased risk of stroke may be linked to reduced blood flow in the brain during certain stages of sleep. |
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Risk factors for Increased Risk of Stroke: | |  | | | | Circulation | Hypertension
Thrombocytosis | Drug Side Effects | Counter-indicators:
Anticoagulant Use | Environment / Toxicity |
Cigarette Smoke Damage | Family History |
Stroke in family members | Lab Values |
Low Total Cholesterol | Researchers have found that as cholesterol levels drop, the risk of hemorrhagic stroke (accounting for 20% of strokes) increased significantly. A person with a cholesterol level below 180mg/dl had twice the risk of that type of stroke when compared with someone at a level of 230mg/dl. |
| Metabolic |
Hemochromatosis (Iron overload) | According to a study published in Neurology, high iron levels in stroke patients may prompt more severe neurological symptoms and possibly increase brain damage. Elevations of iron may intensify post-stroke neurological problems such as increased weakness, speech and orientation difficulties, and decreased levels of consciousness. Stroke patients with high ferritin concentrations may also have larger areas of the brain damaged due to stroke. High body iron stores may increase free radical production in brain cells, thus prompting stroke progression. |
| Nutrients |
Copper Deficiency | A copper deficiency has been associated with weakening of connective tissue that can be a contributing factor for the development of cerebral aneurysms and hemorrhagic strokes. |
EFA (Essential Fatty Acid) Type 3 Requirement | Consuming cold water fish (and probably omega-3 fatty acids) reduced the incidence of stroke in women by 28 percent. This study demonstrated a reduction in clotting type strokes, without an increase in hemorrhagic strokes. |
| Supplements and Medications |
Regular/occasional/history of COX-2 inhibitor use | Animal research suggests that the selectivity of COX-2 inhibitors could create an imbalance that promotes blood clotting and blood vessel constriction. COX-1 makes thromboxane A2, which promotes blood vessel constriction and "stickiness" in blood cells called platelets. COX-2 is the major source of prostacyclin, which helps prevent platelets from clumping and promotes blood vessel dilation. Until further research is completed it may be wise to use COX-2 inhibitors cautiously, if at all, if you are at greater risk of stroke. [Science April 19, 2002;296: pp.539-541] |
| Symptoms - Food - Intake | Counter-indicators:
Moderate/high fruit/vegetable consumption
Moderate/high/low cold water fish consumption |
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Increased Risk of Stroke suggests the following may be present:
Increased Risk of Stroke could instead be:
Recommendations for Increased Risk of Stroke: | |  | | | | Amino Acid / Protein | Taurine | Taurine reduces platelet aggregation, which is how most natural products work in stroke prevention. |
Not recommended:
Glutamine | Animal-based |
Fish Oils | Botanical |
Garlic
Cayenne Pepper (Capsicum frutescens) | Cayenne reduces platelet aggregation (makes the blood less likely to clot) and thus may reduce the risk of clotting strokes. |
Gingko Biloba
Gugulipids
Turmeric Extract, Curcumin | Detoxification |
Chelation Therapy | Diet |
Vegetarian/Vegan Diet | A low incidence of cerebrovascular disease was associated with geographical regions where fresh fruit and vegetable consumption (increased potassium) was high. [Low fruits and vegetables, high-meat diet increase cerebrovascular event risk. Medical Tribune March 10, 1997:26] |
Increased Fruit/Vegetable Consumption | Consuming at least 3 servings per day of fruit and vegetables was associated with reduced risk of stroke and death from stroke, ischemic heart disease and cardiovascular disease in a study of over 9,000 adults, free of cardiovascular disease at the beginning of a 19 year study.[Am J Clin Nutr 2002;76(1): pp.93-99] |
Increased Fish Consumption | Eating fish, one or more times per month, was associated with a reduced risk of ischemic stroke in a study of 43,671 men aged 40 to 75 years followed for 12 years. No associations were found between fish or long-chain omega-3 polyunsaturated fatty acid intake and risk of hemorrhagic stroke.
The use of fish oil or increased consumption of omega-3 fatty acids should have the same effect. [JAMA 2002;288(24): pp.3130-6] |
Low Fat Diet
Caffeine/Coffee Avoidance | Coffee, including decaf, contains significant amounts of Vitamin K which is an important factor for blood coagulation. People at high risk for blood clots, strokes, and heart attacks should avoid coffee and decaf for this reason. |
| Drug |
Conventional Drugs / Information | You can increase the chance of getting the preventive effects and decrease the chance of side effects effects of any medicine by choosing and using it wisely. When it comes to using aspirin to lower the risk of heart attack and stroke, choosing and using wisely means knowing the facts and working with your health professional.
There are many reasons to believe that the drug dipyridamole (300mg per day) will be far more effective in the prevention of heart attacks and strokes than aspirin. Moreover, dipyridamole has none of the harmful side effects of aspirin.
Dipyridamole, like aspirin, inhibits platelet adhesion, and thus tends to prevent the vascular thrombosis of heart attacks and strokes. In a trial referencing the poor response to aspirin, Dipyridamole was added to the treatment protocol and the results were outstanding. Over a two-year period, stroke deaths were decreased by 50%, deaths from myocardial infarction decreased by 38% and deaths from cancer by 25%. [ European Stroke Prevention Study, Lancet, December 12, 1987; pp. 1,371-4] |
| Extract |
Fibrinolytic Enzymes
Policosanol/Octacosanol | Policosanol inhibits the formation of clots, and may work synergistically with aspirin in this respect. 75% of strokes are of the clotting kind. In a comparison of aspirin and policosanol, aspirin was better at reducing one type of platelet aggregation (clumping together of blood cells) but policosanol was better at inhibiting another type. Together, policosanol and aspirin worked better than either alone. |
| Hormone |
Testosterone | Mineral |
Lithium (low dose) | Research in experimental animals with deliberately induced ischemic strokes has shown that lithium reduces the areas of cell death. |
Potassium | Potassium, found in fruits and vegetables, has been shown to decrease the incidence of strokes. A low potassium diet increases the risk of stroke. [Neurology 2002;59(3): pp.314-320] |
| Nutrient |
Lecithin / Choline / GPC | Research on GPC's therapeutic effect in cases of vascular dementia caused by stroke suggests that GPC may promote functional recovery. These studies were uncontrolled so additional research will be necessary to confirm this benefit. |
EPA (eicosapentanoic acid) | EPA reduces platelet aggregation and thus helps prevent those strokes that are due to an abnormal clotting tendency. |
Essential Fatty Acids | High doses of Omega-3 oils reduce platelet aggregation and thus reduce the abnormal clotting tendency which is seen in 75% of strokes. |
Alpha Lipoic Acid | Vitamins |
Vitamin Folic Acid | A study found that people with a dietary intake of at least 300mcg per day of folic acid reduced their risk of stroke and heart disease by 20% and 13%, respectively, compared with those who consumed less than 136mcg of folic acid per day. [Stroke 2002;33: pp.1183-9] |
Vitamin E | Vitamin E at 300 IU or above reduces platelet aggregation, as do the tocotrienols. It is interesting to note that some doctors report that starting to take large doses of vitamin E immediately after a stroke will encourage a higher level of recovery than without the use of vitamin E. For example, instead of having to use a walker, a patient may become mobile with just a cane. This was based on the work of Dr.s Wilfred and Evan Shute. They believed that vitamin E reduces ischemia commonly experienced in myocardial infarction, stroke and renal failure.
These doctors recommended doses from 400 IU to 8,000 IU daily. The usual dose range was 800 to 1600 IU but they reported that they had given 8,000 IU (about 8 grams) without seeing any toxicity.
Yet, a study reported in the June 15, 1999, issue of the "Annals of Internal Medicine" presented data derived from over 40,000 subjects -- male health professionals whose dietary intake, use of vitamin supplements and health status were followed starting in 1986.
The researchers found no difference in risk of stroke between the high vitamin E- and C-consuming subjects and those who consumed lower levels of the two nutrients. Similarly, the researchers found that a higher intake of most of the carotenoids did not decrease the risk in these men of either total stroke or ischemic stroke. Only with respect to lutein (a carotenoid found mainly in dark-green leafy vegetables) did the investigators find a weak trend of decreased risk of stroke with increased intake. |
Vitamin B6 (Pyridoxine) | Vitamin B6 at 150-200mg daily reduces platelet aggregation, and thus may help prevent ischemic (clotting type) strokes. |
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KEY |  | Weak or unproven link |  |  | Strong or generally accepted link |  |  | Proven definite or direct link |  |  | Strongly counter-indicative |  |  | May do some good |  |  | Likely to help |  |  | Highly recommended |  |  | May have adverse consequences |
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