Histamine sensitivity or intolerance (HI) may be considered a type of food intolerance. Because histamine is a primary mediator of an allergic response in the body, consumption of histamine can elicit a similar response. Histamine toxicity is most frequently associated with the consumption of spoiled fish, but has also been associated with aged cheeses and red wines. Elevated levels of histamine occur naturally in these foods. Histamine is also produced within the body.
Histamine is an important second messenger for a number of allergic and pseudoallergic reactions. Millions of humans suffer from disorders like gastrointestinal problems, circulation problems, migraine, asthma, skin diseases as well as other allergy-related symptoms. Too much histamine in the body has been found to be responsible for these diverse patterns of disease. Symptoms of Histamine Intolerance (HIT) appear if incorporated or endogenous histamine cannot be degraded readily by the body. Histamine-Intolerance affects at least 3% of the overall population.
DiAmine Oxidase (DAO) is present almost throughout the whole body, but the main site of action is in the gut. The activity of DAO determines the rate of histamine degradation. If the activity of DAO is inhibited, histamine will be accumulated and then triggers the symptoms of Histamine Intolerance.
The determination of DAO activity in serum shows, whether the patient could have problems with the catabolism of histamine. There is a connection between DAO activity and the appearance of symptoms.
The activity of DAO in serum correlates with the histamine degrading capacity of the organism. The measurement of DAO in serum therefore is the appropriate marker for the diagnostis of Histamine Intolerance and associated diseases. In plasma and serum samples of 34 persons with symptoms of Histamine Intolerance and 78 asymptomatic test persons the DAO activity was determined. All persons with symptoms of Histamine Intolerance showed an activity of DAO below 10 U/ml. These data have been published for the first time at EHRS Congress in May 2003 (Poster).
DAO activity may be inhibited by agents like alcohol or drugs (e.g. ACC, Ambroxol, Aminophyllin, Propafenon, Verapamil)
If a degraded DAO activity is determined a histamine free diet is indicated. SCIOTEC´s newly developed nutritional supplement daocurŽ improves histamine related food intolerance significantly and sustainably. Daocur, daosanŽ or PelLindŽ appear to be available only in Europe at this time.