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| Hirsutism |
Last updated: Jul 17, 2008 |
Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | Other conditions that may be present | Recommendations
Signs, symptoms & indicators of Hirsutism: | |  | | | | Symptoms - Female | Male characteristics
Enlarged clitoris | Symptoms - Hair |
Recent body hair gain
Counter-indicators:
Absence of hirsutism | Symptoms - Reproductive - Female Cycle |
Unexplained missed periods |
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Conditions that suggest Hirsutism:
Risk factors for Hirsutism: | |  | | | | Childhood | Rapid growth but short stature | Hormones |
Elevated Testosterone Level, Female
Hypothalmus / Pituitary / Pineal Function
Low Adrenal Function / Adrenal Insufficiency
Low Progesterone or Estrogen Dominance
Elevated DHEA | Medications |
Birth Control Pill / Contraceptive Issues | Some types of progestins can have androgenic effects and some women on birth control pills with an older formulation can find hair loss or hirsutism is actually promoted by the pill. Synthetically made progestins in birth control pills are not the same as naturally produced progestins like progesterone. Some synthetic progestins are structurally very similar to testosterone and/or estrogen so their androgenic or antiandrogenic effects supplement an individual's natural hormone production levels. The response is quite variable from person to person. While some people have excess hair growth from using the pills others may develop hair loss.
New birth control pill formulations contain progestins with less androgenic activity. For example norgestimate or desogestrel are non-androgenic progestins used in modern birth control pill formulations. Those that find birth control pills promote excess hair growth or hair loss usually find switching to another formulation helps. Excess hair growth is usually reversible, but some dermatologists suggest that once androgenetic alopecia is activated it is difficult to stop or reverse even when the original trigger factor is removed. |
| Symptoms - Skin - Conditions |
History of adult acne | Tumors, Benign |
Ovarian Cysts | Uro-Genital |
Polycystic Ovary Syndrome (PCOS) | It has been traditional to divide patients with hirsutism into those with no elevation of serum androgen levels and no other clinical features ('idiopathic hirsutism') and those with an identifiable endocrine imbalance (most commonly PCOS or rarely other causes). However in recent years it has become apparent that most patients with 'idiopathic hirsutism' have some radiological or biochemical evidence of PCOS on more detailed investigation. |
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Hirsutism suggests the following may be present: | |  | | | | Hormones | Elevated DHEA
Low SHBG | Because SHBG is often low in women with hirsutism, free testosterone is elevated while the total testosterone concentration is normal. This means the free testosterone portion is responsible for increased male characteristics. Just an increase in free testosterone with no increase in total testosterone can produce significant consequences.
Estrogens increase liver manufacture of SHBG. Androgens decrease it. A lack of estrogens can effectively increase available blood androgens. |
Counter-indicators:
Low Testosterone Level, Female
Low DHEA Level | Medications |
Birth Control Pill / Contraceptive Issues | Some types of progestins can have androgenic effects and some women on birth control pills with an older formulation can find hair loss or hirsutism is actually promoted by the pill. Synthetically made progestins in birth control pills are not the same as naturally produced progestins like progesterone. Some synthetic progestins are structurally very similar to testosterone and/or estrogen so their androgenic or antiandrogenic effects supplement an individual's natural hormone production levels. The response is quite variable from person to person. While some people have excess hair growth from using the pills others may develop hair loss.
New birth control pill formulations contain progestins with less androgenic activity. For example norgestimate or desogestrel are non-androgenic progestins used in modern birth control pill formulations. Those that find birth control pills promote excess hair growth or hair loss usually find switching to another formulation helps. Excess hair growth is usually reversible, but some dermatologists suggest that once androgenetic alopecia is activated it is difficult to stop or reverse even when the original trigger factor is removed. |
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Recommendations for Hirsutism: | |  | | | | Drug | Conventional Drugs / Information | If you have seen a medical doctor about hirsutism, you’re probably taking birth control pills, possibly in combination with one or more other drugs. Drugs to retard hirsutism fall into three broad categories:
1. Androgen receptor blockers: Cyproterone, flutamide (Eulexin), and spironolactone (Aldactone). 2. Androgen-suppressing agents: GnRH agonists (Lupron), estroprogestins (birth control pills), corticosteroids, and insulin-sensitizing agents (metformin/Glucophage). 3. 5 alpha-reductase inhibitors: Finasteride (Proscar), eflornithine hydrochloride (Vaniqa).
All of these drugs work to some extent. They have helped some women see measurable reductions in androgen levels and unwanted hair growth. Most have side effects. All are recommended in conjunction with birth control pills, partly to control the side effects of these medications. |
| Hormone | Not recommended:
Testosterone
DHEA | Lab Tests/Rule-Outs |
Test / Monitor Hormone levels | The most important lab test to consider is testosterone and free testosterone. DHEA can be converted to testosterone and so should also be measured. If periods are irregular, FSH and prolactin should also be checked. |
| Physical Medicine |
Topical Applications | Temporary hair removal can be achieved through depilation or epilation. Continued use of these methods works well for many women. More permanent hair removal may be achieved with methods that destroy the hair follicle (electrolysis). The success of these methods depends a great deal on the skill of the practitioner, and your skin and hair type.
Laser hair removal is newer than electrolysis. Lasers use a special light wave that is absorbed by dark hairs and damages the hair follicle. Laser therapies have not been in use long enough for hirsutism to fully determine how permanent the hair destruction is. Laser treatment is expensive also. Laser treatment should not be used by dark-skinned women and is less effective with blond, red or white hair. |
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KEY |  | Weak or unproven link |  |  | Strong or generally accepted link |  |  | Proven definite or direct link |  |  | Strongly counter-indicative |  |  | Very strongly or absolutely counter-indicative |  |  | May do some good |  |  | Likely to help |  |  | Highly recommended |  |  | May have adverse consequences |
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