The Analyst™

Comprehensive diagnosis of your symptoms


  Progesterone Excess  
Search treatments and conditions
Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | It can lead to... | Recommendations


Some women respond to even very low doses of progesterone with symptoms of excess. This is not so much an excess susceptibility as an indication that these women's endogenous production is adequate to provide for their needs. In practice, the range of progesterone tolerance can be quite narrow, and a tiny dose is all that is needed to complete the balance between the estrogens and progesterone.

Approximately 30-40% of menopausal women who take progesterone experience unpleasant PMS-like symptoms such as moodiness, irritably, breast tenderness and muscle aches. Individuals who had significant premenstrual symptoms while they were premenopausal are more likely to be affected. Progestins produce moodiness and irritability by effecting specific sites in the brain. Changing the type of progesterone, the dose, the route of administration and the length of treatment can lessen this effect.

Caution is advised when using saliva for progesterone testing. If you have been using progesterone cream, levels of saliva progesterone may be falsely elevated.

It is also possible to experience allergic reactions to HRT preparations. Women who are allergic to peanuts need to be aware that some hormone replacement preparations including Prometrium contain peanut oil and are capable of producing serious allergic reactions in those who are susceptible.


Signs, symptoms & indicators of Progesterone Excess:
Lab Values - Hormones  High progesterone level

  Reduced/normal/low progesterone level

Symptoms - Mind - Emotional

  Depression with fatigue

Symptoms - Reproductive - Female Cycle

  Breast soreness during cycle

Symptoms - Sleep


Conditions that suggest Progesterone Excess:
Hormones  Low Sex Drive


  Cystitis, Bacterial Bladder Infection
 One mysterious effect in the progesterone intolerant women is bladder problems. Some women have either a great increase in urinary tract infections or a feeling like they are having an infection as soon as they try taking a "normal" progesterone dose. If bladder symptoms start and stop with starting and stopping progesterone, they may be related.

Symptoms - Immune System

  General fungal/yeast infections

Risk factors for Progesterone Excess:
Supplements and Medications  Taking high dose progesterone
  Taking excesssive/on normal dose oral progesterone
 Progesterone in high doses can cause side effects. In one study, oral micronized progesterone at a dose of 400mg per day was associated with dizziness, abdominal cramping, headache, breast pain, muscle pain, irritability, nausea, fatigue, diarrhea, and viral infections.[Medical Economics; 1999:125]

  High sublingual progesterone use
  On moderate/on high dose progesterone

Symptoms - Immune System

  Past general fungal/yeast infections

Symptoms - Reproductive - General

  Being in early pregnancy

Progesterone Excess can lead to:
Hormones  Low Sex Drive

Recommendations for Progesterone Excess:
HormoneNot recommended:

Lab Tests/Rule-Outs

  Test / Monitor Hormone levels

Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
Very strongly or absolutely counter-indicative
Highly recommended
Reasonably likely to cause problems