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| Weakened Immune System |
Last updated: May 12, 2008 |
Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | Other conditions that may be present | It can lead to... | Recommendations
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The Immune system is highly complex and important. A strong and balanced immune system is required for health maintenance. Using natural agents, it is possible to help restore an immune system imbalance or weakness.
The immune system is composed of many interdependent cell types that collectively protect the body from bacterial, parasitic, fungal and viral infections, as well as from the growth of tumor cells. Many of these cell types have specialized functions. The cells of the immune system can engulf bacteria, kill parasites or tumor cells, or kill virus-infected cells. These cells often depend on the T-helper subset for activation signals in the form of secretions formally known as cytokines, lymphokines, or more specifically interleukins.
A shift in cytokine balance can result in many serious disorders. If you have an imbalance between Th1 and Th2, it will be reported elsewhere, along with what to do about it.
Impaired immune function manifests in countless ways and varying degrees. It can exist as a genetic or acquired immunodeficiency, or as a transient or permanent state of depressed immune function due to other factors. In either case, the level of reduced immunocompetence - the body's ability to respond to pathogenic organisms, tumors or tissue damage - is dependent on the nature of the condition, which components of the immune system are affected and to what extent.
A weak or deficient immune system can lead to dysfunctions such as autoimmune diseases (including allergies) and tumor growth. Because immune deficiency does not always present itself in clear patterns, faulty immune function and its specific underlying cause often elude detection. Diagnosis, however, is vital as impaired immune response can pose serious threats to health. With the increasing resistance of pathogens to current antibiotics and anti-fungal medications, the impact of a weak immune system has taken on added significance. Likewise, the daily immune challenges in the face of a more environmentally toxic world have intensified the need for maintaining optimal immune function.
Immune responses can be depressed by various external influences including emotional stress, physical stressors such as inadequate sleep or athletic overtraining, environmental and occupational chemical exposure, UV and other types of radiation, common viral or bacterial infections, certain drug therapies, blood transfusions and surgery. Dietary habits also have an impact on immune response. Excessive fat, alcohol or refined sugar consumption or inadequate protein, calorie, vitamin, mineral or water intake fosters decreased immune performance as well. In addition, the biological state of aging counteracts immune function, particularly after age of 40. Immune deficiencies are also attributed to acquired infections or diseases that target the immune system, such as AIDS, while others, particularly primary immunodeficiency diseases, are often due to genetic abnormalities. Not all primary immunodeficiency diseases are genetically determined, however. Some occur without a known cause. One of the most frequent immunodeficiency diseases, Common Variable Immunodeficiency (CVID), which includes hypogammaglobulinemia, adult-onset agammaglobulinemia, late-onset hypogammaglobulinemia and acquired agammaglobulinemia, usually occurs sporadically and has no clear pattern of inheritance.
Chronic and acute mobilization of immune defenses, induced by a variety of diseases and conditions, places undue stress on the immune system, weakening its capacity to deal effectively with infectious organisms and other immunological requirements elsewhere in the body. Such conditions include, but are not limited to, multiple sclerosis, fibromyalgia, autoimmune disorders in general, primary chronic polyarthritis, chronic candidiasis, cancer, neurodermatitis, ulcerative colitis, Crohn's disease, food and other allergies, Chronic Fatigue Syndrome (CFS) and chemical sensitivities.
General ways to enhance your immune system: Being breastfed as a baby, exercising sufficiently but not excessively, stress management, avoiding food and other allergens, and being well-nourished; supplements such as TMG, zinc, vitamin C and other antioxidants; hormones such as HGH (human growth hormone – can be used homeopathically) and DHEA; colloidal silver, and l-arginine.
A high-quality multivitamin and mineral supplement (especially B6, B12, folate, pantothenic acid, C, zinc, selenium, chromium, and manganese) can be an important starting point. Some are available with thymus extracts in them.
Phytonutrients or foods can be used such as garlic, B-1,3-D glucan, olive leaf (extract), echinacea, ginseng, astralgalus, goldenseal, lemon balm, modified citrus pectin, carnivora (venus fly trap), some mushrooms and plant sterols. Animal-based preparations include thymus proteins, lactoferrin and shark liver oil. Anecdotal evidence supports the use of Bob Beck type electrical devices such as the magnetic pulser and ‘Black Box’ or Zapper.
Nutrient deficiency is a well-known cause of immune system malfunction. It has recently been demonstrated in an animal species is that nutrient deficiency in one generation can affect immune function in succeeding generations, even if they're not nutrient deficient. In that experiment pregnant mice were given a zinc-deficient diet. Their offspring had defective immune function, even though they and their mothers were fed a zinc-adequate diet as soon as they were born. Second and third generations of mice also had defective immune system function (although less severe), all while maintaining a zinc-adequate diet. "This study", the researchers said, "has important implications for public health and human welfare, as the consequences of fetal impoverishment may persist despite generations of nutritional supplementation. Dietary supplementation beyond the levels considered adequate might allow for more rapid or complete restoration of immunocompetence".
Put another way, it is possible that immune system defects suffered by you (including over-reactivity to foods) could be due to nutrient deficiencies suffered by your grandmothers in the months before you were born. It's also possible that diet supplementation (vitamins, minerals, and so on) above the usual levels might aid in a more rapid recovery.
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Signs, symptoms & indicators of Weakened Immune System: | |  | | | | Symptoms - General | Slow recovery from colds
Counter-indicators:
Rapid recovery from colds | Symptoms - Immune System |
History of infections | Symptoms - Metabolic |
Frequent colds/flus | Lowered immune function may result in an increase in acute illnesses such as colds and the flu, but over time it also may contribute to the development of chronic disease. |
| Symptoms - Respiratory |
Recent/chronic productive cough |
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Conditions that suggest Weakened Immune System:
Risk factors for Weakened Immune System: | |  | | | | Allergy | Allergy / Intolerance to Foods (Hidden) | Food allergies divert some of the immune system's resources away from preventing and dealing with illness. Thus, continuous consumption of a food which is causing symptoms weakens your immune system. A weakened immune system enables infections and cancerous growths to develop and take hold. Many patients report that they suffer from more than one symptom or illness when reintroducing a known food allergen into their diet after a period of abstinence. |
| Drug Side Effects |
Chemotherapy Side-Effects/Risks | Environment / Toxicity |
Mercury Toxicity / Amalgam Illness | In vitro studies suggest that even low, environmentally relevant exposure levels of mercury, which are not toxic, still contribute to immune dysfunction by interfering with proper lymphocyte functioning. [Scand J Immunol 50(3): pp.233-241] |
Gulf War Illness | Habits |
Overtraining, Effects | High performance athletes have chronically lowered immune systems. The high level of training leaves their immune systems frequently depressed so that, for example, if a group of athletes is training together, a flu bug will rapidly make its way around. It is said that, in immunological terms, high-performance athletes are some of the least healthy people around. |
| Hormones |
Low Adrenal Function / Adrenal Insufficiency | Immunity |
Chronic Fatigue / Fibromyalgia Syndrome | Immune dysfunction has been documented in CFS. CFS has been called chronic fatigue immune dysfunction syndrome (CFIDS). The immune dysfunction may result in recurrent infections, often with normally nonpathogenic organisms such as Candida albicans or bowel parasites. Treat any bowel infections or imbalances and any sinusitis or nasal congestion. |
| Infections |
Lyme Disease | Lab Values |
Low White Count | Medical Procedures |
Recent/previous transplant surgery | Mental |
Stress | Studies show that stress and depression affect the body physically and can weaken the immune system. Suppressor-T cells, also known as CD8 cells, are part of the immune system. Studies by Manuck et al in 1991 showed that psychological stressors induced cell division among CD8 cells, thereby increasing the number of CD8 cells and suppressing immune function. However, this response was only seen in those subjects who also showed high heart rate change and catecholamine change during the stressors i.e. those people who are significantly affected by stress. |
| Nutrients |
Zinc Requirement
Supplementation Need | Inadequate vitamin and mineral intake has been associated with immune deficiency and improper energy metabolism. It appears that most immune system dysfunction actually results from a vitamin and/or mineral deficiency rather than protein deficiency. |
| Organ Health |
Cirrhosis of the Liver | Supplements and Medications |
Prednisone use | A side-effect of treatment with prednisone can be an increased susceptibility to infection. Prednisone must be used cautiously by HIV-positive individuals because this drug is immunosuppressive and can increase the risk of contracting opportunistic infections. People who have undergone radiation, chemotherapy or other immune-suppressing treatments also typically have low thymus function. |
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Weakened Immune System suggests the following may be present: | |  | | | | Drug Side Effects | Chemotherapy Side-Effects/Risks | Habits |
Overtraining, Effects | High performance athletes have chronically lowered immune systems. The high level of training leaves their immune systems frequently depressed so that, for example, if a group of athletes is training together, a flu bug will rapidly make its way around. It is said that, in immunological terms, high-performance athletes are some of the least healthy people around. |
| Immunity |
AIDS / Risk | AIDS has a weakening effect on the immune system, resulting in many possible opportunistic infections, some of which would be rarely encountered otherwise. These include pneumocystis pneumonia carinii, candida albicans, toxoplasmosis, cryptosporidiosis, cryptococcal meningitis, tuberculosis, Non-Hodgkins lymphoma, cytomegalovirus and mycobacterium infections. Women also experience increased susceptibility to recurrent vaginitis and cervical cancer (due to decreased resistance to human papiloma virus).Children are susceptible to all the complications demonstrated by adults, plus an increased risk of acute bacterial infection, such as otitis media, meningococcal meningitis, lobar pneumonia, conjunctivitis, ear infections and tonsillitis. |
| Musculo-Skeletal |
Rheumatoid Arthritis | People with rheumatoid arthritis, who for a long time were thought to have overactive immune systems, instead may have exhausted immune systems. A study at the Mayo Clinic has shown for the first time that patients with rheumatoid arthritis have prematurely aged immune systems. Patients 20 to 30 years old had a collection of T-cells that looked like they belonged to 50 to 60 year olds. |
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Weakened Immune System can lead to:
Recommendations for Weakened Immune System: | |  | | | | Animal-based | Thymic Factors
Shark Liver Oil | Botanical |
Medicinal Mushrooms
Garlic
Astragalus Root (Astragalus membrinaceus) | Astragalus is establishing its importance in the long-term recovery of people with moderate to severely weakened immune systems. It increases the activity of white blood cells and increases interferon production (the substance that prevents the development of a virus in living cells) in the body. These attributes make it suitable for use as a preventative against recurring colds, flu and bronchitis, as well as an adjunct to treating chronic illnesses and supporting long term recovery from debilitating viral infections. |
Elderberry (Sambucus nigra) | Although viruses cannot be treated with antibiotics, which are effective only against bacteria, the body's immune system has many natural defenses against virus infections. Infected cells produce interferons and other cytokines (soluble components that are largely responsible for regulating the immune response to viruses), which can signal adjacent uninfected cells to mount their defenses, enabling uninfected cells to impair virus replication. Elderberry stimulates favorable cytokine production. [Eur Cytokine Netw 2001 Apr-Jun; 12(2): pp.290-6] |
Chlorella / Algae Products
Noni | Noni protected mice from developing cancer as would be expected in a trial conducted at the University of Hawaii School of Medicine. Noni acted not by killing the cancer cells, but by stimulating their immune system. |
Ginseng, Korean - Chinese / Asian (Panax ginseng) | At the Institute of Traditional Chinese Medicine in Jilin Province, researchers in the pharmacology department evaluated the effects of ginseng on immune responses. The immune responses of mice were tested with different dosages of extracts obtained either from the leaf or the root of ginseng. Significant changes in the response of the reticuloendothelial (RES) system were found, especially with moderate doses of the root extracts. Larger doses did not improve the response. RES cells are the immune system components that devour foreign organisms without leaving their original sites in the liver, spleen and other tissues of the body.
However, ginseng has not yet been proven effective for bolstering the immune system. |
| Diet |
Sugars Avoidance / Reduction | Sugars have a depressive effect on the immune system. |
Raw Food Diet | Uncooked food is a necessary prerequisite for an intact immune system. The therapeutic effect is complex, and a variety of influences of raw food on the immune system have been documented. Such effects include antibiotic, anti-allergic, tumor-protective, immune modulating and anti-inflammatory actions. In view of this, uncooked food can be seen as a useful adjunct in the treatment of an altered or weakened immune system. [ Fortschr Med 1990 Jun 10;108(17): pp.338-40 (German)] |
Artificial Sweetener Avoidance | Splenda has been demonstrated to reduce thymus size, suggesting a poorer immune response potential. |
Coconut | Extract |
Beta 1,3 Glucan | Beta glucan, having its own immune stimulating properties, will help other substances like antibiotics, antifungals and antiparasitics to work better. |
Bioperine (Black Pepper)
Glyconutrients | There are many testimonies available on the Internet regarding how glyconutrients products has seemed to improve their immune systems. People report that they get sick less frequently, and have more energy. While more study is needed, those who are looking for a solution to improve their health, might consider taking such a product to see if they are benefited. |
Plant Sterols / Sterolins (Phytosterols) | Plant sterols are an effective immune balancer. Sterols and related compounds called sterolins are special fats found in plant foods, such as seeds, nuts, and plant oils. Sterols and sterolins have been shown to restore immune balance, which is beneficial for those with infections, stress-induced immune suppression, allergies, or rheumatoid arthritis and other autoimmune conditions [Alternative Medicine Review, 2001, vol. 6, no. 2] |
| Homeopathy |
COBAT / Taurox SB | Lab Tests/Rule-Outs |
Test for Food Allergies
Test for DHEA
Test Zinc Levels | Normal zinc levels are required for a strong immune system. |
| Mineral |
Selenium
Iron
Colloidal Silver | Miscellaneous |
Reading List | The Maker's Diet by Dr. Jordan Rubin, NMD. |
| Nutrient |
TMG (Tri-methyl-glycine) / SAMe
DHA (docosahexaenoic acid) | It is known that adding fish oil, which is rich in omega-3 fatty acids with EPA and DHA, to your diet is reported to decrease several markers of the immune system. However, whether it is EPA, DHA or a combination of both that affects the functioning of the immune system remains unclear. A study was conducted to determine the immune system effects of adding EPA-rich or DHA-rich oils to the diet of healthy humans.
The study, which was a double blind parallel and placebo-controlled, consisted of 42 healthy adults who were randomly chosen to receive either placebo oil (olive oil), EPA-rich oil or DHA-rich oil for a four-week period. Samples of blood were drawn before and after taking the oil.
The results of the study showed that the effects of the EPA were significantly different from the DHA. While those who took the DHA-rich oil showed a decrease in T lymphocyte activation, which helps keep virus-infected or malignant cells in check, there was no significant change among the EPA-rich oil group.
Conclusions from the study revealed that the use of DHA supplementation, but not EPA, restrained the T lymphocyte activation. It was also discovered that neither EPA nor DHA significantly affected any other area of the immune system. [ American Journal of Clinical Nutrition April 2004;79(4) pp.674-681] |
Beta-Carotene | A daily intake of beta-carotene at 25,000 IU (16mg) appears to be optimal to strengthen immunity. |
Lycopene | Lycopene supplementation has been found to boost immune function in the elderly. In one trial, 15mg of lycopene per day increased natural killer cell activity by 28% in 12 weeks. [Proc Nutr Soc 1998;57:3A (abstr)] |
| Oxygen / Oxidative Therapies |
Ozone / Oxidative Therapy | Physical Medicine |
Hydrotherapy
Calming / Stretching Exercises | This study points to specific protective benefits as related to shingles and aging. There may a broader, yet untested protective benefit against infectious disease.
Tai chi chih, the Westernized version of the 2,000-year-old Chinese martial art characterized by slow movement and meditation, significantly boosts the immune systems of older adults against the virus that leads to the painful, blistery rash known as shingles, according to a new UCLA study.
The 25-week study, which involved a group of 112 adults ranging in age from 59 to 86, showed that practicing tai chi chih alone boosted immunity to a level comparable to having received the standard vaccine against the shingles-causing varicella zoster virus. When tai chi chih was combined with the vaccine, immunity reached a level normally seen in middle age. The report appears in the April issue of the Journal of the American Geriatrics Society, currently online.
The results, said lead author Michael Irwin, the Norman Cousins Professor of Psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, confirm a positive, virus-specific immune response to a behavioral intervention. The findings demonstrate that tai chi chih can produce a clinically relevant boost in shingles immunity and add to the benefit of the shingles vaccine in older adults.
"These are exciting findings, because the positive results of this study also have implications for other infectious diseases, like influenza and pneumonia," said Irwin, who is also director of the UCLA Cousins Center for Psychoneuroimmunology. "Since older adults often show blunted protective responses to vaccines, this study suggests that tai chi is an approach that might complement and augment the efficacy of other vaccines, such as influenza."
The study divided individuals into two groups. Half took tai chi chih classes three times a week for 16 weeks, while the other half attended health education classes - including advice on stress management, diet and sleep habits - for the same amount of time and did not practice tai chi chih. After 16 weeks, both groups received a dose of the shingles vaccine Varivax. At the end of the 25-week period, the tai chi chih group achieved a level of immunity two times greater than the health education group. The tai chi chih group also showed significant improvements in physical functioning, vitality, mental health and reduction of bodily pain
The research follows the success of an earlier pilot study that showed a positive immune response from tai chi chih but did not assess its effects when combined with the vaccine.
The varicella zoster virus is the cause of chickenpox in kids. Children who get chickenpox generally recover, but the virus lives on in the body, remaining dormant. As we age, Irwin said, our weakening immune systems may allow the virus to reemerge as shingles. Approximately one-third of adults over 60 will acquire the infection at some point. |
| Vitamins |
Multiple Vitamin Supplement
Vitamin E
Vitamin C (Ascorbic Acid) |
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KEY |  | Weak or unproven link |  |  | Strong or generally accepted link |  |  | Proven definite or direct link |  |  | Strongly counter-indicative |  |  | May do some good |  |  | Likely to help |  |  | Highly recommended |
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