The Analyst™

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  Histadelia (Histamine High)  
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Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | Recommendations


Histadelia, is more common in males and is characterized by elevated blood levels of histamine. It is estimated that 15-20% of schizophrenics are probably histadelic. This is also known as an undermethylation problem or being under-methylated. This condition is characterized by low levels of serotonin, dopamine, and norepinephrine, high whole blood histamine and elevated absolute basophils. This population has a high incidence of seasonal allergies, OCD tendencies, perfectionism, high libido, sparse body hair, and several other characteristics. In severe cases involving psychosis, the dominant symptom is usually delusional thinking rather than hallucinations. They tend to speak very little & may sit motionless for extended periods. They may appear outwardly calm, but suffer from extreme internal anxiety.

The treatment of histadelia requires great patience because six to ten weeks are often needed before the beginning of significant improvement. The treatment usually takes twelve months to complete. To find out more about this see Mental Illness: The Nutrition Connection, a book by Carl Pfeiffer. The prognosis is good if the histadelic patient cooperates with treatment and works to give up detrimental addictions.


Signs, symptoms & indicators of Histadelia (Histamine High):
Supplements and Medications  Helped by antihistamine
  No effect with/worse by benzodiazapines

Symptoms - Allergy

  Excess/using medication for allergy/ mucous
 Histamine can cause additional mucus production.

Symptoms - Environment

  Good tolerance of cold
  Poor tolerance of heat

  Good tolerance of heat
  Poor tolerance of cold

Symptoms - Gas-Int - General

  Unexplained nausea

Symptoms - General

  Poor pain tolerance

  Good pain tolerance

Symptoms - Hair

  Light/minimal body hair

Symptoms - Head - Mouth/Oral

  Excess/abundant saliva in mouth

  (Very) dry mouth

Symptoms - Metabolic

 Histamine speeds up metabolism producing a tendency towards hyperactivity.

  Frequent colds/flus

Symptoms - Mind - Emotional


  A lack of phobias

Symptoms - Mind - General

  Being highly motivated
 Those with elevated histamine (histadelics) tend to work compulsively.

  A hard-driving personality
 Histadelics tend to work compulsively.

  Being an antisocial person
  Good creativity/imagination
 Histadelics are often highly creative.

Symptoms - Reproductive - General

  No difficulty achieving orgasm
  Strong sexual desire

  Weak sexual desire

Symptoms - Skeletal

  Joint pain/swelling/stiffness

Symptoms - Skin - General

  Excess perspiration
  Warm skin

Conditions that suggest Histadelia (Histamine High):
Addictions  Addictions / Addictive Tendencies
 Nutritional treatment for drug and alcohol users will depend on the results of a test for blood histamine levels. In one series of such analysis, all users proved to have high histamine levels, leading the scientist to conclude that this abnormality - with its impact on brain function - is a major force in creating addiction. [Nutrition Guide for the Prevention and Cure of Common Ailments and Diseases, Carlton Fredericks, PhD. p.58]


  Allergic Rhinitis / Hay Fever

Lab Values - Chemistries




  Bipolar Disorder, Manic-Depressive
 About 35% of bipolar patients have high histamine levels.

 Histadelics are often chronically and suicidally depressed.

  Obsessive-Compulsive Disorder (OCD)
 Histadelics are often prone to obsessions, compulsions, and addictions.

 Histadelia, prominent in males, means too much histamine in the blood. Estimated to affect 15-20% of patients classified as schizophrenic. Symptoms include hyperactivity, compulsions, obsessions, inner tensions, blank mind episodes, phobias, chronic depression, and strong suicidal tendencies. Physical signs can include little tolerance for pain, rapid metabolism, lean build, profuse sweating, seasonal allergies, and frequent colds.


 The overarousal seen in histadelia may contribute to insomnia.


  Muscle Pains (Myalgia)

Risk factors for Histadelia (Histamine High):
Lab Values - Chemistries  Possible histadelia


  Methylation, Insufficient
 Elevated histamine and/or elevated basophils indicate undermethylation. [Willam Walsh, Ph.D., past senior scientist, Pfeiffer Treatment Center]

Supplements and Medications

  Antihistamine use
  SAMe use

Symptoms - Gas-Int - General

  History of unexplained nausea

Symptoms - Skeletal

  Slender fingers / toes
 Histadelics often have long fingers and toes.

  Stubby fingers / toes
 Histadelics often have long fingers and toes.

Recommendations for Histadelia (Histamine High):
Amino Acid / Protein  Methionine
 Methionine supplements lower blood levels of histamine by increasing histamine breakdown.

Not recommended:


  Histamine-Restricted Diet
  Vegetarian/Vegan Diet
 Nutritionists recommend a low-protein, high complex carbohydrate diet. Histidine, which is more common in animal proteins, should be avoided as it can be converted into histamine.

Lab Tests/Rule-Outs

  Test Copper Levels
 Testing serum or hair copper levels is usually adequate for evaluating copper status when low levels of copper are suspected and hair contamination with copper can be ruled out. When in doubt, it would be better to use more accurate tests such as the 24 hour urine copper or serum ceruloplasmin.

  Test Histamine Levels
  Test Folic Acid Levels
 Under certain conditions, such as anticipated or actual pregnancy, a simple lab test for serum folate levels is advisable. If the test results show low levels, supplementation should be considered to prevent potential birth defects.

  Test Zinc Levels
  Test for Manganese Levels


 Calcium, methionine, SAMe, magnesium, zinc, TMG, omega-3 fatty acid, B6, inositol, vitamin A, C and E have some antifolate activity.

 Copper levels may be low to normal in patients with histadelia. Copper is part of the enzyme histaminase, which is involved in the metabolism of histamine. Some suggest that copper should be avoided when bipolar symptoms are present. Testing will help confirm a person's status.


  TMG (Tri-methyl-glycine) / SAMe
 One thing that is absolutely certain is that methionine and/or SAMe usually harm low-histamine (overmethylated persons)….. But are wonderful for high-histamine (undermethylated) persons. The reverse in true for histadelic (undermethylated) persons, who thrive on methionine, SAMe, Ca and Mg….. But get much worse if they take folates & B-12 which can increase methyl trapping. [Willam Walsh, Ph.D., past senior scientist, Pfeiffer Treatment Center]

  Essential Fatty Acids
 Omega 3 essential fatty acids can be beneficial.

Not recommended:
  Lecithin / Choline / GPC
 Choline is anti-dopaminergic and often makes undermethylated patients worse. [Principles of orthomolecularism, R.A.S. Hemat, MB;BCh, FRCSI, Dip. Urol.]



  Vitamin Inositol Hexaniacinate
 Inositol is especially helpful for undermethylated persons (for example most persons with OCD), but can cause negative side effects in those who are overmethylated. Since Inositol is one of the primary second messengers in neurotransmission, it's surprising it isn't more commonly used. It's especially useful in reducing anxiety and enhancing sleep.

To enhance sleep for a 160 lb person, we usually recommend 650mg tablets, 1-3 as needed for sleep. Persons who have difficulty falling asleep should take it 30-60 minutes before sleep. Persons whose main problem is waking up in the middle of the night should take it at bedtime.

We've often given as much as 3-4 grams/day to undermethylated persons who respond beautifully to Inositol, and these persons take it morning, noon, and evening.

I once gave an invited presentation at a symposium at an APS annual meeting... in which data on megadoses (15-30 g) of Inositol were reported by another speaker. The volume of Inositol used seemed extreme to me, and would present daunting compliance problems. I believe such huge doses of Inositol are unnecessary, if methionine, calcium, B-6, and other nutrients to combat undermethylation are used. However, massive doses of Inositol might be needed if one tries to combat OCD with Inositol alone.

Regardless of the form of inositol, its use should be started as a trial, with close monitoring of the patient. We've found that persons who achieve improved sleep after inositol are excellent candidates for taking it throughout the day also. I recommend you be alert for adverse side effects, especially with persons with severe anxiety or panic symptoms. [Willam Walsh, Ph.D., past senior scientist, Pfeiffer Treatment Center]

  Vitamin B6 (Pyridoxine)
  Vitamin C (Ascorbic Acid)
  Vitamin A
  Vitamin E

Not recommended:
  Vitamin B12 (Cobalamine)
 Histadelic (undermethylated) persons, get much worse if they take folates & B-12 which can increase methyl trapping. [Willam Walsh, Ph.D., past senior scientist, Pfeiffer Treatment Center]

  Vitamin Folic Acid
 Histadelics should avoid supplemental folic acid as it can produce excess histamine. In fact, anti-folate drugs may be required. Folic acid increases depression in histadelic patients and a trial of folic acid could be used to distinguish between histapenics and histadelics. In extreme cases, folic acid in food or in multivitamins is enough to produce the adverse effects.

Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
Weakly counter-indicative
Strongly counter-indicative
Very strongly or absolutely counter-indicative
May do some good
Likely to help
Highly recommended
May have adverse consequences
Avoid absolutely


Allergy:  Hypersensitivity caused by exposure to a particular antigen (allergen), resulting in an increased reactivity to that antigen on subsequent exposure, sometimes with harmful immunologic consequences.

Anxiety:  Apprehension of danger, or dread, accompanied by nervous restlessness, tension, increased heart rate, and shortness of breath unrelated to a clearly identifiable stimulus.

Basophil:  The basophils account for about 1% of the granulocyte count (60 to 75% of the white blood cells). They release chemicals such as histamine and play a role in the inflammatory response to infection.

Chronic:  Usually Chronic illness: Illness extending over a long period of time.

Dopamine:  A neurohormone; precursor to norepinephrine which acts as a stimulant to the nervous system.

Hallucination:  A false or distorted perception of objects or events, including sensations of sight, sound, taste, smell or touch, typically accompanied by a powerful belief in their reality.

Histamine:  A chemical in the body tissues, produced by the breakdown of histidine. It is released in allergic reactions and causes widening of capillaries, decreased blood pressure, increased release of gastric juice, fluid leakage forming itchy skin and hives, and tightening of smooth muscles of the bronchial tube and uterus.

Metabolism:  The chemical processes of living cells in which energy is produced in order to replace and repair tissues and maintain a healthy body. Responsible for the production of energy, biosynthesis of important substances, and degradation of various compounds.

Noradrenaline:  (Norepinephrine): A catecholamine hormone secreted from the adrenal medulla and post-ganglionic adrenergic fibers in response to hypotension or emotional stress.

pH:  A measure of an environment's acidity or alkalinity. The more acidic the solution, the lower the pH. For example, a pH of 1 is very acidic; a pH of 7 is neutral; a pH of 14 is very alkaline.

Serotonin:  A phenolic amine neurotransmitter (C10H12N2O) that is a powerful vasoconstrictor and is found especially in the brain, blood serum and gastric membranes of mammals. Considered essential for relaxation, sleep, and concentration.