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Hyperpituitarism is defined to mean too much of one, or perhaps two, of the hormones from the adenohypophysis. This may be due either to autonomous over-production (i.e., from a primary adenoma in this gland [microadenoma, macroadenoma] - cancer of the adenohypophysis is very rare Cancer 79: 804, 1997, J. Neurosurg. 96: 352, 2002), from excess production of hypophyseal stimulating factors or underproduction of inhibiting factors, or loss of inhibition following the destruction of other endocrine glands.
Pituitary disease, like other endocrine disease, is fairly common, and is generally treatable if it is discovered. The anterior pituitary (adenohypophysis), produces ACTH, TSH, FSH, LH, GH, and prolactin. If the input from the hypothalamus is interrupted, the adenohypophysis makes more prolactin and less of the other hormones.
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Adenoma: An ordinarily benign growth of epithelial tissue in which the tumor cells form glands or gland-like structures that tend to exhibit glandular function.
Anterior: In the front or forward part of the organ or toward the head of the body.
Cancer: Refers to the various types of malignant neoplasms that contain cells growing out of control and invading adjacent tissues, which may metastasize to distant tissues.
CAT Scan: (Computerized Axial Tomography scan). A scanning procedure using X-rays and a computer to detect abnormalities of the body's organs.
Gynecomastia: Occurs when the male breast is enlarged. The size can vary from a slight puffiness to full female-like breasts. It literally means "female-like breasts".
Hormones: Chemical substances secreted by a variety of body organs that are carried by the bloodstream and usually influence cells some distance from the source of production. Hormones signal certain enzymes to perform their functions and, in this way, regulate such body functions as blood sugar levels, insulin levels, the menstrual cycle, and growth. These can be prescription, over-the-counter, synthetic or natural agents. Examples include adrenal hormones such as corticosteroids and aldosterone; glucagon, growth hormone, insulin, testosterone, estrogens, progestins, progesterone, DHEA, melatonin, and thyroid hormones such as thyroxine and calcitonin.
Hypothalamus: An important supervisory center in the brain regulating many body functions. Despite its importance in maintaining homeostasis, the hypothalamus in humans accounts for only 1/300 of total brain weight, and is about the size of an almond.
MRI: Magnetic Resonance Imaging. A technique used in diagnosis that combines radio waves and magnetic forces to produce detailed images of the internal structures of the body.
Pituitary: The pituitary gland is small and bean-shaped, located below the brain in the skull base very near the hypothalamus. Weighing less than one gram, the pituitary gland is often called the "master gland" since it controls the secretion of hormones by other endocrine glands.
Prolactin: An anterior pituitary peptide hormone that initiates and maintains lactation.