Hypoalbuminemia is conventionally defined as albumin levels below 3.5gm/dl. However, levels don't have to fall as low as 3.5 before trouble appears. Low levels of albumin have been linked to all cancers, with the risk of developing cancer rising as albumin falls. We have adjusted the range for "normal" albumin levels upward to reflect a more optimal level and to provide an earlier warning regarding potential health issues for those whose level is at the lower end of what most doctors would consider "normal".
High cholesterol level is a well-known risk factor for heart disease. But low cholesterol in combination with low levels of the protein albumin in the blood may indicate a high risk of decline and death in elderly people. In a 7-year period, those with low cholesterol and albumin had 3.5 times the risk of dying, investigators have found. The risk of functional decline, such as the ability to do housework or walk up and down stairs, was also greater in people with a combination of low albumin and cholesterol compared with those with normal cholesterol and albumin levels. Low albumin in the blood can be an indicator of malnutrition, and possibly related to infection, inflammation, stress due to surgery, trauma, or liver or kidney disease.
Because about half of the calcium in your blood is bound by albumin, a normal calcium level with a low albumin level means there is too much calcium in your blood.