| | | Botanical | Horsetail Grass (Equisetum arvense)
 | Horsetail contains silicon, and it has been suggested as a possible natural treatment for osteoporosis. One study has examined horsetail for osteoporosis. In that study, 122 Italian women took horsetail dry extract or Osteosil calcium 270 mg twice daily (a horsetail-calcium combination used in Italy for osteoporosis and fractures). Although both groups who took horsetail did improve bone density, the study was poorly designed. |
Green / Oolong / BlackTea (Camellia sinensis)
 | Drinking regular tea was associated with a small improvement in bone mineral density, but was not associated with the risk of hip or forearm/wrist fractures. This study was done in the United States using 4,979 women over 50 years old who were followed for an average of 4years. [Am J Epidemiol 2003;158(8): pp.772-81] |
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Diet |
Dairy Products Avoidance
 | Harvard University's landmark Nurses' Health Study, which followed 78,000 women over a 12-year period, found that the women who consumed the most calcium from dairy foods broke more bones than those who rarely drank milk. Summarizing this study, the Lunar Osteoporosis Update (November 1997) explained: "This increased risk of hip fracture was associated with dairy calcium. If this were any agent other than milk, which has been so aggressively marketed by dairy interests, it undoubtedly would be considered a major risk factor."
A study published in the January, 2001 edition of the American Journal of Clinical Nutrition examined the diets of 1,035 women, particularly focusing on the protein intake from animal and vegetable products. Deborah Sellmeyer, M.D., found that animal protein increases bone loss. In her study, women with a high animal-to-vegetable protein ratio experienced an increased rate of femoral neck bone loss. A high animal-to-vegetable protein ratio was also associated with an increased risk of hip fracture. Dr. Sellmeyer states: "Sulfur-containing amino acids in protein-containing foods are metabolized to sulfuric acid. Animal foods provide predominantly acid precursors. Acidosis stimulates osteoclastic activity and inhibits osteoblast activity."
Milk has been called "liquid meat". The average American eats five ounces of animal protein each day in the form of red meat and chicken, at the same time consuming nearly six times that amount (29.2 ounces) per day of milk and dairy products. How ironic it is that the dairy industry continues to promote the cause of bone disease as the cure!
Many foods naturally contain an abundance of calcium. One must wonder why Asians traditionally did not get bone-crippling osteoporosis... that is, until they adopted the "American Diet", a diet of milk and dairy products. |
Sugars Avoidance / Reduction
Caffeine/Coffee Avoidance
Vegetarian/Vegan Diet
 | Calcium loss is reduced with a vegetarian type diet.
A study published in the January, 2001 edition of the American Journal of Clinical Nutrition examined the diets of 1,035 women, particularly focusing on the protein intake from animal and vegetable products. Deborah Sellmeyer, M.D., found that animal protein increases bone loss. In her study, women with a high animal-to-vegetable protein ratio experienced an increased rate of femoral neck bone loss. A high animal-to-vegetable protein ratio was also associated with an increased risk of hip fracture. Dr. Sellmeyer states: "Sulfur-containing amino acids in protein-containing foods are metabolized to sulfuric acid. Animal foods provide predominantly acid precursors. Acidosis stimulates osteoclastic activity and inhibits osteoblast activity."
A 1994 report in the American Journal of Clinical Nutrition showed that when volunteers are switched from a typical American diet to a diet eliminating animal proteins, calcium losses were reduced to less than half of baseline values. [Remer T, Manz F. Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. Am Clin Nutr 1994;59:1356-61]
Higher consumption of fruits, vegetables and cereals was associated with greater femoral bone mineral density (in men) in a study of 907 older adults. [Am J Clin Nutr 2002;76(1): pp.245-252] |
Alcohol Avoidance
 | Alcohol is toxic to the cells that form bones and inhibits the absorption of calcium. |
Alcohol Consumption
 | ASN Spokesperson Stephanie Atkinson, PhD, explained the study which looked at the effects of alcohol on bone mineral density in older people, and said that "moderate alcohol consumption was shown to contribute to stronger bones (measured as hip and spine bone mineral density). The positive effect on bone was most notable at 1-3 glasses of beer in men and more than 2 glasses of wine or liquor (but not beer) for women. The bone preserving ingredients may be the silicon in beer and resveratrol in wine in addition to the alcohol. Such positive effects on bone must be balanced against the risk of falls and bone fractures caused by consuming excessive alcohol." [16 Mar 2009] |
Soy Isoflavones (genistein, daidzein)
 | Higher intake of dietary phytoestrogens (isoflavones) was associated with higher lumbar spine and hip bone mineral densities in a study of 357 postmenopausal southern Chinese women. [J Clin Endocrinol Metab 2001;86(11): pp.5217-5221]
One month of treatment with a soy isoflavone extract reduced the excretion of bone resorption markers, in a placebo-controlled study of 23 healthy perimenopausal women. [J Am Coll Nutr 2002;21(2): pp.97-102]
Another showed that postmenopausal women with the highest level of isoflavone consumption had greater bone mineral density at the spine. [J Women's Health Gender-Based Med, 2002;11(1): pp.69-78]
If using soy products to reduce osteoporosis risks, consider taking 80mg or more per day of soy isoflavones. One year of supplementation with a soy extract containing 80mg isoflavones in addition to calcium (500mg) and vitamin D3 (125IU) modestly improved hip and trochanter bone mineral density among women with low initial bone mass, compared with placebo OR a lower dose of soy extract containing only 40mg isoflavones with calcium and vitamin D3. This was the conclusion from a well-controlled study of 203 Chinese postmenopausal women. [ J Clin Endocrinol Metab 2003;88(10): pp.4740-7]
Ipriflavone (7-isopropoxyisoflavone) is a synthetic derivative of naturally occuring isoflavones, flavonoid compounds found in soybeans and other plants.
For some time, postmenopausal women in Europe and Japan have taken ipriflavone supplements to maintain the density and strength of their bones and to guard against fractures and other complications associated with the bone-thinning disease known as osteoporosis.
In the United States, ipriflavone supplements have recently become available. Ipriflavone's bone-strengthening effect is enhanced by taking both vitamin D and calcium along with it.
Because ipriflavone does not have direct estrogenic effects, it may be suitable for use in aging men with bone loss, as well as in women.
However, in 2006, a separate analysis of isoflavones, a component of soy, was also carried out. Dr. Frank Sacks, a professor of nutrition at the Harvard School of Public Health in Boston. According to Dr. Sacks, there are is no evidence that it could reduce symptoms of menopause like 'hot flashes' or even osteoporosis. |
Not recommended:
High/Increased Protein Diet
 | After looking at 34 published studies in 16 countries, researchers at Yale University found that countries with the highest rates of osteoporosis including the United States, Sweden, and Finland are those in which people consume the most meat, milk, and other animal foods. They also found that African Americans, who consume on average more than 1,000mg of calcium per day, are nine times more likely to experience hip fractures than are South African blacks, whose daily calcium intake is only 196mg. On a nation-by-nation basis, people who consume the most calcium have the weakest bones and the highest rates of osteoporosis. Only in those places where calcium and protein are eaten in relatively high quantities does a deficiency of bone calcium exist, due to an excess of animal protein. The association between the intake of animal protein and fracture rates appears to be as strong as the association between cigarette smoking and lung cancer.
HOWEVER, it was found that although protein intake in the presence of a low-calcium diet may increase net calcium spill in the urine and aggravate bone loss, adequate protein (average 80gm per day from all sources) and calcium intake (along with vitamin D) taken together act synergistically to reduce bone loss and have improved hip fracture healing and lessened the recurrence of hip fracture. [Am J Clin Nutr, 2002; 75:pp. 609-610, 773-779]
So if you have osteoporosis and prefer a higher protein diet, just make sure you are getting enough or the right kind of calcium and vitamin D. |
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Drug |
Conventional Drugs / Information
 | Servier, a leading independent French research-based pharmaceutical company, discovered and developed Protelos. Protelos has been recently licensed across Europe in the treatment of postmenopausal osteoporosis to reduce the risk of vertebral and hip fractures. It is the first agent of its kind with a dual action on bone metabolism, simultaneously increasing bone formation and decreasing bone resorption. This action rebalances bone turnover in favour of the formation of new and strong bone.
The results of two large-scale phase III clinical trials have shown that Protelos is effective at reducing the risk of vertebral and hip fractures in postmenopausal osteoporotic women. Results published in the New England Journal of Medicine from the first major clinical trial show that in women with existing vertebral fractures the risk of new vertebral fractures is halved within a year and in the longer-term. This efficacy has also been confirmed in patients without fracture at baseline. Recent results from the second major clinical study show that Protelos also significantly reduces the risk of hip fracture in postmenopausal osteoporotic patients . These results show the efficacy of Protelos whatever the severity of the disease and the site of fracture. Throughout its development Protelos was shown to be safe and well tolerated. Protelos is easy for patients to take; one sachet daily diluted in water taken at bed time.
Although Evista is frequently recommended for osteoporosis, a study indicated that calcium and vitamin D alone may produce the same benefit.
Two years of treatment with calcium at 500mg per day and vitamin D3 at 400-600IU per day plus placebo increased iliac crest bone mineral density similarly to calcium and vitamin D3 plus raloxifene (Evista; 60 mg/d or 120 mg/d) in a randomized, three-arm study of 54 postmenopausal women with osteoporosis. Compared to baseline, all treatments shifted the mean degree of bone mineralization to closely resemble that of premenopausal bone. [ J Clin Endocrinol Metab 2003;88(9):4199-4205]
A long-term study of the most widely used osteoporosis drug has found that many women can discontinue the drug after five years without increasing their fracture risk for as long as five more years.
The study on alendronate (fosamax) was led by researchers at the University of California, San Francisco, and findings are published in the December 27, 2006 issue of the "Journal of the American Medical Association." The research also showed that women at very high risk of painful spine fractures might be better-off continuing treatment.
"This has important implications as it has not been known whether treatment of osteoporosis should be continued indefinitely," said lead author Dennis Black, PhD, professor in the UCSF Department of Epidemiology and Biostatistics. "Because women with osteoporosis, particularly older post-menopausal women, often need to take multiple drugs, this would be welcome news for this group."
Fosamax Once Weekly (alendronate sodium) increased bone mineral density (BMD) more than Actonel Once-a-Week (risedronate) with similar tolerability, according to results of the Fosamax Actonel Comparison Trial (FACT). This is the first U.S. head-to-head study comparing FDA approved once weekly osteoporosis treatments in postmenopausal women with osteoporosis. In this study, Fosamax provided greater increases in BMD at all sites measured as early as six months, and lowered levels of biochemical markers of bone turnover further within the normal pre-menopausal range than Actonel within three months. Reducing and stabilizing bone turnover, which leads to increased bone density, are important factors in improving bone strength in patients with osteoporosis.
However, Merck, maker of osteoporosis drug Fosamax, may have “seriously under reported” the risks of "jawbone death" related to the drug, according to the American Association of Oral and Maxillofacial Surgeons. A class-action lawsuit has been filed claiming that Merck knew about the risk of jawbone death but hid it from the public.
"Jawbone death" is associated with the use of a bisphosphonate class of drugs (to which Fosamax belongs). Also known as Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ), is a serious side effect that destroys the bone in the jaw, and is difficult to treat.
BRONJ was reported by oral surgeons, who noticed the condition among patients treated with intravenous forms of bisphosphonates in 2003. A broader warning of BRONJ was issued for the entire class of drugs in 2005.
Fosamax is prescribed to about 10 million men and women -- mostly postmenopausal women -- each year to help increase bone density, with annual sales of $3 billion. Over 190 million prescriptions for oral bisphosphonate drugs have been dispensed worldwide. [LawyersAndSettlements.com July 19, 2007] |
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Habits |
Aerobic Exercise
 | Physical activity may help reduce fracture risk by enhancing bone strength and improving bone quality.
Please read the following study summary carefully. It demonstrates the value of exercise.
Twelve months of supplementation with calcium citrate (800mg) plus exercise (aerobic, weight-bearing and weight-lifting exercise three times per week) increased trochanteric bone mineral density among women who did not use hormone replacement therapy (HRT) in a study of 320 healthy, non-smoking postmenopausal women who did or did not use HRT. HRT users who exercised and took calcium experienced increased femoral neck, trochanteric and lumbar spine BMD, while women who used HRT and calcium but did not exercise had no change in BMD. [Osteoporos Int 2003;14(8):637-43] |
Sunlight / Light Exposure
Tobacco Avoidance
 | Studies have shown that women who smoke one pack of cigarettes per day have on average 5-10% less bone density at menopause than do nonsmokers. |
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Lab Tests/Rule-Outs |
Test for Bone Resorption
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Mineral |
Calcium
 | A study found that a supplement containing calcium, manganese, zinc and copper prevented bone loss in postmenopausal women, whereas calcium alone was ineffective. Calcium supplements for osteoporosis should contain other minerals as well, or the form of calcium used should have been proven to be of benefit.
Intake of supplemental calcium (1000mg per day or more) and vitamin D was associated with reduced tooth loss (due to bone loss) over a five year period in a study of 145 healthy subjects aged 65 years and older who completed a 3-year trial of the effect of calcium and vitamin D supplementation on bone loss from the hip, as well as a 2-year follow-up study after discontinuation of the study supplements. [Am J Med 2001;111(6): pp.452-56]
The recommended daily intake levels for prepubertal children (ages 4-8 years) is 800 mg/day; adolescents (ages 9-18 years), 1300 mg/d; pregnant or lactating women (18 years), women and men (ages 19-50 years), 1000 mg/d; women and men over 50 years, 1500 mg/d.
Another study concluded: "The small effect of calcium supplementation on bone mineral density in the upper limb is unlikely to reduce the risk of fracture, either in childhood or later life, to a degree of major public health importance. It may be appropriate to explore alternative nutritional interventions, such as increasing vitamin D concentrations and intake of fruit and vegetables." [BMJ Sept 2006]
These results with calcium are not that encouraging. However, there are products using compounds of calcium which have been proven to reverse osteoporosis. Examples are AdvaCAL, 3A Calcium (Active Absorbable Algal) and a new one - AlgaeCal Plus.
All 400 participants have now completed the first 6 months of the AlgaeCal Bone Health Program, and results are exceeding expectations by reversing bone loss, and increasing bone mineral density in post menopausal women.
C.E.O. of AlgaeCal International Dean Neuls says "we are very excited with these results because our natural osteoporosis treatment is accomplishing what no other calcium supplement has been able to do; we are actually reversing bone loss."
AlgaeCal International and Integrative Health Technologies Inc (IHTI) launched an independent clinical trial to study the effectiveness of the AlgaeCal Bone Health Program. The program is a natural osteoporosis treatment that consists of a plant based calcium supplement, a strontium citrate supplement and an exercise program.
Kaats, adds "Although only a few subjects have now completed the one-year tests, analysis of the 6-month test results revealed that instead of the expected decline in bone mineral density, over two-thirds of women over 50 years of age increased their bone densities. Subjects in the 50+ adult group achieved an annualized increase in bone density of over 1% instead of the expected 1% decline for people of this age." Kaats goes on to say "The most dramatic improvement was found in a 64-year old woman who improved her bone density at a 10% a year rate and a cancer patient being treated with chemotherapy who also improved his bone density." Here is a link to the AlgaeCal home page, where these products can be ordered. |
Magnesium
 | A high percentage of the American population is considered to have some degree of magnesium deficiency [JAMA 1990, 263: 3063]. In a study, magnesium supplements were given to 19 postmenopausal women on estrogen replacement therapy with low bone density. After 1 year of magnesium supplementation 12 of the women no longer had low bone density [J Reprod Med 1990, 35: p.503]. Magnesium supplementation has been associated with a 1 - 8% increase in bone density [Magnesium Research 1993, 6: p.155]. |
Salt Intake Reduction
 | Sodium (salt) tends to leach calcium out of the bones. |
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Vitamins |
Vitamin K1/K2
 | In a 3 year study of postmenopausal women, vitamin D, minerals and vitamin K were used to determine vitamin K's effect on bone loss. The use of vitamin K, along with other nutrients, reduced femoral neck bone loss, but not lumbar spine bone loss when compared to a similar supplement list without vitamin K. [Calcif Tissue Int 2003;73(1): pp.21-6]
Numerous studies published in 2008 have shown that vitamin K not only helps regulate calcium balance in the body to ensure calcium remains in the bones and away from heart valves and arteries, but it has demonstrated numerous other health benefits. In addition, scientists have been able to develop a form of the nutrient that stays in the body longer than previous forms and is more cost effective to purchase.
Maintaining consistent levels of calcium is essential, especially as we age. Studies have shown that a vitamin K2 deficiency can lead to brittle bones and hardening of the arteries. Conversely, a new study shows that restoring the nutrient can actually reverse the normal aging process of arterial calcification. Another study published in 2008 demonstrated that postmenopausal women in Japan who took both Fosamax and vitamin K2 for one year had a greater increase in neck bone density than women who only took Fosamax. And an in vitro study published in January 2008 led doctors to conclude that taking a combination of vitamins D3 and K1 can offer a "low-cost strategy for laying down new bone material."
"Clinically, vitamin K2 sustains the lumbar bone mineral density (BMD) and prevents osteoporotic fractures in patients with age-related osteoporosis, prevents vertebral fractures in patients with glucocorticoid-induced osteoporosis, increases the metacarpal BMD in the paralytic upper extremities of patients with cerebrovascular disease, and sustains the lumbar BMD in patients with liver-dysfunction-induced osteoporosis. Vitamin K deficiency, as indicated by an increased circulating level of undercarboxylated osteocalcin, may contribute to osteoporotic fractures. Even though the effect of vitamin K2 on the BMD is quite modest, this vitamin may have the potential to regulate bone metabolism and play a role in reducing the risk of osteoporotic fractures." [Iwamoto J, Takeda T, Sato Y. Curr Pharm Des 2004; 10:pp. 2557-2576.]
So for osteoporosis prevention and treatment, vitamin D, vitamin K2, and calcium, used in combination should result in the desired effect. |
Not recommended:
Vitamin A
 | In a study of 72,337 women aged 34-77 years, there were 603 incidences of hip fracture. Women taking a vitamin A supplement had a 40% increased risk of hip fracture. This risk was increased among those who consumed at least 3,000 mcg/day of retinol equivalents of vitamin A from the diet. [JAMA January 2, 2002;287(l): pp.47-54]
Animal, human, and laboratory research suggest an association between greater vitamin A intake and weaker bones. Researchers have also noticed that worldwide, the highest incidence of osteoporosis occurs in northern Europe, a population with a high intake of vitamin A. However, decreased biosynthesis of vitamin D associated with lower levels of sun exposure in this population may also contribute to this finding.
To further test the association between excess dietary intake of vitamin A and increased risk for hip fracture, researchers in Sweden compared bone mineral density and retinol intake in approximately 250 women with a first hip fracture to 875 age-matched controls. They found that a dietary retinol intake greater than 1,500 mcg/day (more than twice the recommended daily intake for women) was associated with reduced bone mineral density and increased risk of hip fracture as compared to women who consumed less than 500 mcg per day. [Ann Intern Med. 1998;129: pp.770-778]
If osteoporosis is present, and vitamin A treatment is indicated for other reasons, it would be wise to limit the duration of high dose vitamin A use.
There is no evidence of an association between beta-carotene intake and increased risk of osteoporosis. Current evidence points to a positive osteoporosis risk in postmenopausal women who are consuming increased amounts of food or supplemental vitamin A in its retinol form only. |
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